In 2004, Francis Collins made the case in Nature for a large prospective cohort study of genes and the environment in the United States. The Secretary’s Advisory Committee on Genetics, Health, and Society, an advisory panel in the Department of Health & Human Services, was asked to gather information on the issues involved in embarking on such a project. Their report can be found here, and they have now asked for public input and comment. As much as $3 billion (or more) could be devoted to such a project, if the decision is made to go forward. The comment period is open until 31 July.