BACE1 modulates myelination in the central and peripheral nervous system

The proteinase BACE1 is part of the mechanism that releases the toxic amyloid Abeta fragment from APP, but its ‘real’ function has been enigmatic. This study reports that myelination is impaired in BACE1 null mice, and suggests that the myelination signal neuregulin-1 is a BACE1 substrate.