On the ball

For those of you not afflicted by World Cup fever, turn away now.

For the rest of us addicts, it’s finally here…

Despite England’s tepid performances we are through to the second round and now that Rooney’s back, we’re obviously going all the way to the final. Of course we are. Seriously. Come on now, stop laughing.

I’ve noticed that one or two chem blogs out there have also turned their attention to Germany 2006, including Paul at The Endless Frontier who is spurring on Team USA (who won’t be going to the final, or even the second round – sorry Paul). Also check out the special feature at nature.com.

Just how distracting/addictive/consuming is the World Cup?

A recent story reports that the World Cup may cost the British economy a staggering £4 billion in lost productivity – although not as many people may stay away from work as they did four years ago, the broadcast of the games live on the web by the BBC is likely to have a significant impact (I was going to put the link in here, but then I would feel partially responsible for that £4 billion – and of course, I have no idea what the link is and have no intention of going there…). Another study, however, claims that the influence of the World Cup may be just the opposite and that it may lead to increased motivation and foster greater team spirit.

This all reminded me of a review article published by K C Nicolaou back in 1996 concerning the total synthesis of brevetoxin B. In the final stages of the synthesis, there was an unexpected delay, which is best described in Nicolaou’s own words:

Projections were made that by the end of August 1994 we would reach our destination and submit the papers for publication early in September. I was convinced that these five men would carry out their mission as planned, for by then I was well aware of their talents and commitment. As it happened, one more August would come and go before we would arrive at “Ithaca”. In my calculations, I had neglected a small detail, a detail that became an important factor, and one that “Poseidon” would exploit at our expense and inflict one more delay before the final success…

During the summer of 1994, when the final campaign towards brevetoxin B was taking place, the World Cup in Soccer was hosted in the U. S., and all the members of the brevetoxin B team were either European or Japanese! Placing such soccer fanatics on the team for this highly demanding operation was rather unfortunate. Well, you can never think of everything in total synthesis! Brevetoxin B could not, however, escape for much longer, and before the end of the fall in that year it was destined to yield to the enthusiasm and pressure of these relentless professionals. Needless to say, this victory was to serve well as a consolation to each one of them for their countries’ not winning the World Cup!

So there you have it, World Cup fever may or may not be bad for business, but it certainly gets in the way of lab work. Now, which games are on today…

Stuart

Stuart Cantrill (Associate Editor, Nature Nanotechnology)

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Papers in the June 2006 issue

For your commenting pleasure. All links are to abstracts. Posted on September 21, 2006.

Meshi et al., Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment

Doi et al., Impaired light masking in dopamine D2 receptor–null mice

Kleim et al., BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex

Jordan et al., Adaptation of gender derived from biological motion

Mevorach et al., Opposite biases in salience-based selection for the left and right posterior parietal cortex

Shen et al., The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells

Anggono et al., Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis

Shintani et al., Eph receptors are negatively controlled by protein tyrosine phosphatase receptor type O

Mizuguchi et al., Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons

Koizumi et al., Doublecortin maintains bipolar shape and nuclear translocation during migration in the adult forebrain

Müller-Smith et al., Midline radial glia translocation and corpus callosum formation require FGF signaling

Soler-Llavina & Sabatini, Synapse-specific plasticity and compartmentalized signaling in cerebellar stellate cells

Glickfeld & Scanziani, Distinct timing in the activity of cannabinoid-sensitive and cannabinoid-insensitive basket cells

Wang et al., Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo

Yanai et al., Palmitoylation of huntingtin by HIP14is essential for its trafficking and function

Ding et al., RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion

Yin et al., Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells

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