Archive by category | Nature Methods papers

Top downloads for May ’09

Below I’ve posted the rankings of the six most popular papers published in our May issue based on downloads and page-views during May. The most popular paper by a rather large margin was a paper describing mRNA-Seq analysis of single cells. Regular readers of this blog won’t be surprised by this given the high level of interest that next-generation sequencing papers generally receive.  Read more

Reproducible proteomics

Our June issue, which went live online yesterday, includes an Analysis paper describing the results of a large-scale study to try to get to the root causes of irreproducibility in mass spectrometry-based proteomics. Despite the novel and valuable biological applications made possible by proteomics and the continuing impressive technological advances in mass spectrometry, the technology has been unable to completely shed its reputation of being poorly reproducible.  Read more

Top downloads for March ’09

It’s a new month and time to see how papers published in Nature Methods have been received by our readers. I alway find it fascinating to see how the numbers of downloads compare to our opinion of each paper. I’ve listed the original research papers we published that received the most unique views (HTML) and downloads (PDF) in March in order of popularity and broken them down between papers published in the March issue and papers published in prior months.  Read more

Can doing things differently enhance reproducibility?

Intuitively most of us would agree that standardized conditions in scientific experiments ensure reproducibility. If I know how something was done and exactly replicate the setup and protocol, I should get the same results. The authors of a Perspective in the April issue of Nature Methods argue otherwise when it comes to behavioral experiments done with live animals.  Read more

Top downloads for February ’09

It is always interesting to see how papers we publish are received by the community and one useful metric is the number of times a paper is viewed or downloaded. Authors also like to see this information when their paper was one of the most heavily viewed papers.  Read more

The social lives of fruit flies

It has been appreciated for a while that fruit flies interact with each other, but studying these interactions is quite difficult. In fact, this is a general problem in understanding animal behavior – the measurements are incredibly tedious to make and to quantify. In a paper published yesterday in Nature Methods (Dankert et al, 2009), Heiko Dankert, Pietro Perona, David Anderson and colleagues now automate the process, using the power of machine vision to analyse social interactions in pairs of fruit flies.  Read more

GPCR oligomerization redux

Many receptors form functional dimers or higher order oligomers on the cell surface. A number of reports have also shown with various levels of certainty that G protein-coupled receptors (GPCRs) di- or oligomerize. In December 2006 we published an Article by Simon Davis and colleagues that challenged how bioluminescence resonance energy transfer (BRET) was being used to investigate GPCR dimerization. In particular, conclusions about β-adrenergic receptor (β-AR) dimerization were challenged. The paper was accompanied by a News and Views article by Martin Lohse.  Read more