Archive by category | Proteomics

Computable sugars: some computational resources in glycoscience

Computable sugars: some computational resources in glycoscience

As glycoscience advances, labs will increasingly want to ask questions about glycosylation sites on a protein or the structure of a sugar, says Raja Mazumder, a bioinformatician at George Washington University. They might ask for example: are there glycosyltransferases that are expressed in liver but not in the heart, or, which ones are overexpressed by a factor of three in more than two cancers. Such questions require infrastructure building, he says, because right now there is no mechanism to allow such queries. But he and others are building such capabilities. Mazumder along with William York at the University of Georgia are starting to build a glycoscience informatics portal.  Read more

Matthias Mann awarded Louis-Jeantet Prize for medicine

The Louis-Jeantet Foundation awarded its prestigious 2012 Louis-Jeantet Prize for medicine to Matthias Mann last Tuesday, Jan 24th, for his contributions to mass spectrometry and the field of proteomics.  Matthias Mann, Director of the Department of Proteomics and Signal Transduction at the Max-Planck Institute of Biochemistry in Martinsried, and his co-workers have developed several of the key technologies that have made modern proteomics possible, including mass spectrometry-based identification of proteins from electrophoretic gels and the SILAC method that underlies many recent quantitative proteomics studies. The foundation highlighted, in particular, his quantitative analyses of cancer cell proteomes, and the promise this work may hold for the future diagnosis and treatment of cancer (e.g. Geiger et al, 2010; Lundberg et al, 2010; Nagaraj et al,  2011).  Read more