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Call for submissions: Reproducible data processing

Scientific Data is inviting submissions that provide compelling examples of how portable computing technologies can be used to create transparent, reproducible descriptions of data processing workflows. Submissions considered for this collection should describe valuable research datasets that involve some form of computational processing in their production. Authors should provide source code for all data processing steps in a way that would allow others, including referees, to easily understand and execute all processing steps.  Read more

Call for submissions: Multiomics data

Scientific Data is inviting submissions that release and describe datasets from studies that employed multiple ‘omic’ profiling technologies, including, but not limited to, genomics, epigenomics, transcriptomics, proteomics and metabolomics. Submitted articles may be considered for inclusion in a special article collection to be published at the journal.  Read more

Author’s Corner: Revisiting the personalities of wild chimpanzees

Chimpanzee in a patch of sunlight in 2010

Early on in her behavioural observations of the chimpanzees at what is now known as Gombe National Park, Jane Goodall was struck by their personalities, which were as distinct as our own1. However, upon sharing her observations with a ‘respected ethologist’, she was told that, yes, animals differed in their behaviour, but that this was best ‘swept under the carpet’ (pp 11-12)2.  Read more

An open approach to Huntington’s disease research

SONY DSC

Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a mutation in the huntingtin gene1. The progressive break down of brain neuronal cells in HD patients leads to deteriorating mental and physical abilities over a 10-20 year period prior to death, the symptoms often described as having Parkinson’s disease, Alzheimer’s disease and amyotrophic lateral sclerosis (ALS) simultaneously2. At the start of the huntingtin gene there is a CAG trinucleotide repeat region that encodes a stretch of poly-glutamine residues in the amino-terminus of the encoded protein. This repeat tract is expanded in HD patients. The repeat length of this region correlates with the age of symptom onset3. Affecting approximately 1 in 10,000 of the population4, rare juvenile forms of the disease exist in patients with the longest CAG expansions, although adult-onset HD patients typically have between 40-50 CAG repeats with symptom onset beginning between the ages of 35-50.  Read more