If you were given a choice between a large protein-protein interaction data set obtained by high-throughput experiments and another data set extracted from a collection of small-scale experiments via literature mining, which one would you trust more?

We think that high-throughput approaches to protein-protein interaction study have made constant progress over the past few years. In the May Editorial, we explain why we think it is now time to abandon the idea that the body of information on protein interactions available in the literature is superior to results of high-throughput experiments.

What about you: When it comes to protein-protein interaction studies, are you a high-throughput friend or foe?