Science in fiction

In July of 2007, we highlighted several popular nonfiction science books on our “summer reading” lists in our Editorial. Given the abundance of nonfiction books on scientific topics, many of which are written for the general public, it was not too hard to identify a short list of stellar examples of science writing. For this month’s Editorial, we sought to highlight fiction books with realistic scientists (even more specifically, biologists) as main characters in laboratory settings.

This did not turn out to be a very easy task, because few books fall under the label of “science in fiction” or “lab lit”, and stories about biologists doing believable biology research are even rarer. The list of books of this sort featured in the Editorial is not comprehensive, but it is perhaps nearly so. If you are interested in finding more books in the science-in-fiction genre, LabLit.com is an excellent resource. This online magazine is edited by Jennifer Rohn, the author of Experimental Heart (one of the books profiled in the Editorial) and a practicing cell biologist at University College London. Rohn was inspired to try to raise the profile of books in this genre after reading Cantor’s Dilemma by Carl Djerassi, when she was in graduate school. LabLit.com has become quite a popular site, and now more than 80 books are profiled on the “lab lit list”. Many of these books have been best-sellers or won awards, indicating that there is interest from the general public in stories about scientists.

Despite the more in-your-face forms of entertainment – television, movies, the internet – an old-fashioned novel is still a source of pleasure for many of us. It’s also a fantastic medium for overturning stereotypes about scientists, and for getting more people interested in science and for educating them about what scientists do. It also allows authors to draw attention to the important issues of ethics and the societal and personal impacts of scientific research. The books highlighted in the July Editorial are great examples of realistic representations of biologists in page-turning stories.

Happy summer reading!

Cover error?

Some readers may recall that we ran a cover on our January 2008 issue with an error that keen readers picked up immediately. After that experience we were pretty certain that some readers would question our use of what appears to be a common house fly on our current cover, instead of Drosophila melanogaster, the topic of several papers in the issue. Our keen-eyed readers have indeed noticed the discrepancy and notified us by email or posted about it on their blog here and here.

We acknowledge that it may seem as though an impostor sits on the ‘throne’ where the rightful heir should reside but as with all our cover art, we make cover decisions based primarily on artistic and visual impact rather than scientific accuracy. Our cover artist does a wonderful job creating or finding candidate images and we fell in love with this image as soon as we saw it and nothing she could do with the Drosophila melanogaster images we had on hand could match the weight and presence of the image. We felt anything else would fail to do justice to the weight of the content on the other side of the cover.

One reader kindly provided a photograph of Drosophila melanogaster that he took on a white background as an example of what could be done in a short amount of time and in five minutes of fun I mocked up a cover with it so our readers unfamiliar with Drosophila melanogaster can see what all the fuss is about.

flycovers

No doubt there will continue to be occasions in the future when a scientific inaccuracy on the cover gives rise to comments from our readers and we welcome their comments even if we are unable to devote more resources to trying to ensure that covers are as scientifically accurate as they are aesthetically pleasing.

Top downloads for May ’09

Below I’ve posted the rankings of the six most popular papers published in our May issue based on downloads and page-views during May. The most popular paper by a rather large margin was a paper describing mRNA-Seq analysis of single cells. Regular readers of this blog won’t be surprised by this given the high level of interest that next-generation sequencing papers generally receive.

A surprising omission from the list is the paper by Allan Bradley and colleagues describing the use of transposons carrying reprogramming factors to generate iPS cells followed by removal of the transposons from the genome. After analyzing the download stats it looks like the explanation for this is the fact that we express-published the paper online ahead of the other papers from the May issue so it would appear soon after a similar paper in Nature. So although initial downloads were very high, they were trailing off during May. In contrast, downloads of newer papers from the May issue were still at their peak during May.

Discerning readers will note that the last paper in the list is actually a Correspondence. Because Correspondences sometimes contain original data we will now be including these in the rankings with original research papers when appropriate.

Top 6 research papers published in the May issue

1. mRNA-Seq whole-transcriptome analysis of a single cell

2. Universal sample preparation method for proteome analysis

3. Super-resolution video microscopy of live cells by structured illumination

4. Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency

5. Single molecule–sensitive probes for imaging RNA in live cells

6. Massively parallel exon capture and library-free resequencing across 16 genomes

As in past months, there has been very little movement in the list of most popular papers published in months prior to the issue month being analyzed. The main changes this month are the appearances of two papers from the April issue and an old paper from 2007 describing new far-red fluorescent proteins Katushka and mKate. The only explanation I come come up with for this is the appearance of an article in Science from Roger Tsien that compared the performance of a new fluorescent protein they developed to mKate instead of the more recent improved variant mKate2 published in this paper in The Biochemical Journal.

Top 10 research papers published prior to the May issue

1. Mapping and quantifying mammalian transcriptomes by RNA-Seq

2. Genome-wide analysis of transcription factor binding sites based on ChIP-Seq data

3. Stem cell transcriptome profiling via massive-scale mRNA sequencing

4. Amplification-free Illumina sequencing-library preparation facilitates improved mapping and assembly of (G+C)-biased genomes

5. Photoactivatable mCherry for high-resolution two-color fluorescence microscopy

6. Stable knockdown of microRNA in vivo by lentiviral vectors

7. Bright far-red fluorescent protein for whole-body imaging

8. Global mapping of protein-DNA interactions by digital genomic footprinting

9. Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing

10. Lifeact: a versatile marker to visualize F-actin