Method of the Year 2010: Optogenetics

The time to celebrate methods has come and this year we have chosen to devote our end of year special feature to Optogenetics.

While neuroscientists will hardly need any introduction to this booming technology, recent developments have shown that this technique can go beyond controlling the activity of neurons in the brain and has the potential to open new avenues of experimentation across multiple other biological fields as well.

The term optogenetics was only coined 4 years ago but the technology has already matured to the point that it is having a substantial impact on basic biological research. Because of the transformative effect that it has already had in neuroscience studies and the excitement of its future prospects in other fields, it’s nomination as Method of the Year has not been a difficult one.

You can read more about this choice in the editorial of our January issue and access all the content of our special issue here.

We hope that you will share our excitement for this technology and we welcome any comments on our selection!

Brains at work

Neuroscience is a field where much still needs to be learned and for that, technology development is increasingly necessary. Recent developments have greatly expanded our capacity to visualize the activity of neurons using genetically encoded fluorescent probes and optogenetic tools now enable precise modulation of this activity.

But the brain is contained in a protective skull and peeking into it is usually an invasive process. In this month’s editorial we discuss recent technical developments and future prospects that will take us a step closer to a minimally invasive form of ‘transcranial neuroscience’. Despite the big progress, much work remains but we are hopeful that with the right technology and motivation, the field will soon approach the holy grail of performing non-invasive cellular-level functional studies of the entire brain.

Any thoughts about this? Tell us what’s on your mind!