If you’re attending the Society for Neuroscience meeting this year (#SfN13), join us for our panel discussion: ‘Tackling the terabyte: how should research adapt to the era of big data? Read more
It really is an embarrassment of riches here at Nature these days, what with so many excellent neuroscience-related studies emerging. Just in the last couple of weeks, we’ve had the following studies: … Read more
Sometimes an experiment will just reach off the page and slap you in the face, demanding attention. This happens to me every so often and I must admit, our latest paper from the lab of Florien Engert induced such an experience. There have been several cool, technical tours-de-force (is that proper grammar??) over the last few years involving different creatures navigating in a virtual environment while neuronal activity was monitored. These include a mouse running on a spherical treadmill, as well as a fly marching along a similar treadmill-style ball. But in these examples, having the subject head-fixed (for the stability of recordings in the brain, either with electrodes or through imaging) was moderately non-intrusive since walking motions were independent of the head. The same can’t be said for the subject in this latest example of a virtual reality navigator: a wriggling, swimming fish. Therefore, a more creative solution had to be sought and in a paper published online yesterday, Ahrens, Engert and colleagues decided that paralysis was the way to go in order to follow the neural activity of this navigating fish. Read more
It is commonly believed that distinct mini-networks of neurons, firing together, may be the means by which memories and other conceptual encoding requirements are handled in the brain. However, it is only recently that we have had the tools available to directly test the sufficiency of such a mechanism. Today, a new study in Nature from the lab of Susumu Tonegawa documents the ability to use light as a means to activate distinct subsets of neurons responsible for the encoding of fear memories. Read more
You warily walk into a dark compartment, wondering if there is food inside. Suddenly there is a loud tone and you feel an uncomfortable surge of electricity through your feet. This goes without saying, but it won’t take long before you will learn to be afraid of that tone. However, over time, you hear the tone without the shock, and slowly (foolishly??) accept that the previous connection may no longer hold. Read more
I’m currently attending the Winter Conference on Neural Plasticity in lovely St. Kitts & Nevis and I’ll be tweeting when I can from #wcnp12 when the Internet access in the room decides to cooperate. Read more
Alzheimer’s disease (AD) is a devastating neurodegenerative disease that could become an even more massive public health problem than it already is, if current projections hold. Some predict that by 2050, 1 in 85 individuals will be affected by the disease. Currently, there is no cure, but there are neurotransmitter-enhancement-based strategies to slow down the cognitive deficits [the loss of cholinergic neurons is implicated in some of the memory problems associated with AD so therefore, pharmacological enhancement of brain acetylcholine concentration can partially alleviate some memory-based symptoms.] However, as with many neurodegenerative diseases, these stop-gap treatments only work for so long, until the cells responding to neurotransmitter supplementation treatments die off completely. Therefore, diverse strategies designed to cure or at least slow down AD are imperative. Read more
After a brief resurrection during the 2012 Society for Neuroscience meeting, the time has come to get a more regular series going on the old Action Potential blog! There are a lot of great (neuro)science writers out there (just to name a few,) so here at Nature, we wanted to be able to offer something different, something unique to supplement your weekly intake of neuroscience knowledge. Therefore, my editorial colleague I-han Chou and I will regularly blog about the latest neuro papers we publish in the journal, with particular attention to the back stories and our reasoning for offering publication. Read more
Our June editorial discusses the relationship between web traffic and citations. Specifically, can one predict how well any particular paper is cited years after publication, based solely on the number of downloads it receives immediately following its appearance online? Our preliminary analysis suggests that this relationship not only exists, but is surprisingly strong. Read more