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Archive by tag | method development

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03 Nov 2017 | 5:40 PM

A conversation about neuroscience

Posted by Vivien Marx | Categories: Neuroscience, This and That

A conversation about neuroscience

Nature research journal editors speak with Eric Nestler and Robert Greene about neurobiology and the Society for Neuroscience (SfN) 2017 annual meeting.  Read more

Tags:

  • brain
  • method development
  • Nature Communications
  • Nature Methods
  • Nature Neuroscience
  • neurobiology
  • neuroscience
  • Society for Neuroscience

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05 Oct 2017 | 11:14 AM

A celebration of cryo-EM

Posted by Allison Doerr | Categories: Chemistry, General Interest, Structural Biology

Here at Nature Methods, we were quite excited yesterday to wake up to the news that the Nobel Prize in Chemistry had been awarded to Jacques Dubochet, Joachim Frank, and Richard Henderson for their seminal developments in cryo-electron microscopy (better known as cryo-EM) which now enable high-resolution biomolecule structure determination. This is a technique we have been watching closely since 2013, when the first papers (including one of our own) realizing the capability of near-atomic-resolution structure determination with cryo-EM were published.  Read more

Tags:

  • chemistry
  • method development
  • nobel prize
  • proteins

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12 Dec 2016 | 11:39 AM

Building OpenSPIM systems

Posted by Vivien Marx | Categories: General Interest

Build your own OpenSPIM system

Tuning reagents, software, or equipment is all in a day’s work in the lab. Building instruments from scratch, however, is a task more typical for physicists who might 3D print or machine the parts they need and then assemble them into the instrument they want. They might construct an instrument for a specific experiment or develop a design that helps hundreds of labs. That model could go on to be modified and hacked in a variety of ways.  Read more

Tags:

  • light-sheet microscopy
  • method development
  • Open-source hardware
  • Open-SPIM

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28 Mar 2013 | 12:55 PM

Technology development at the heart of ‘big neuroscience’

Posted by erika pastrana | Categories: Editorials, General Interest, Neuroscience

European and US initiatives aiming to advance our understanding of brain function depend on new technologies.    … Read more

Tags:

  • method development
  • technology

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28 Feb 2012 | 5:05 PM

The potential and perils of trying new methods

Posted by Daniel Evanko | Categories: Editorials, Journal Policy

The remit of Nature Methods has always been to publish new or improved methods that will have an immediate practical impact on researchers working at the bench. But unfortunately, ‘new’ methods aren’t always ready for primetime, and the more novel the method the more likely it is that all the kinks aren’t yet worked out.  Read more

Tags:

  • method development

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30 Jan 2012 | 5:54 PM

Head-to-head comparisons of methods and tools

Posted by erika pastrana | Categories: Editorials

Choosing the best tool or method for a particular experiment can be a daunting task. Finding the right choice can mean much time and many resources and an improper one can lead to poor or inaccurate results.  Read more

Tags:

  • analysis
  • method development
  • optogenetics
  • super-resolution

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28 Oct 2011 | 11:00 AM

Where’s your ground truth?

Posted by Daniel Evanko | Categories: Computational, Editorials, Microscopy & Imaging

When using or developing experimental and observational methods it is crucial to assess the method performance in an effort to ensure that the information it provides reflects reality. For experimental biologists this often means conducting carefully chosen control experiments with alternative methods or different experimental settings. More rigorous assessment, particularly for high-throughput or large-scale methods, often requires the use of ‘ground truth’ or ‘gold standard’ data sets. But talk to different people and you will get different answers regarding what ‘ground truth’ or ‘gold standard’ data is. This often includes a nice historical explanation of where the term ‘ground truth’ comes from.  Read more

Tags:

  • analysis
  • data
  • method development
  • software

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29 Sep 2011 | 11:00 AM

Academic inventions

Posted by Daniel Evanko | Categories: Editorials, General Interest

Over the past 30 years the ties between academic research and commercial enterprise have increased enormously. Much of this increase has involved attempts by universities to capitalize on the intellectual property created by their research scientists using the US patent system. The Editorial in the October issue of Nature Methods discusses this change and the challenges facing academics interested in commercializing their innovations.  Read more

Tags:

  • commercialization
  • law
  • method development
  • Obama
  • patents

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31 Aug 2011 | 2:01 PM

Building a better mouse test

Posted by Allison Doerr | Categories: Editorials, Model Organisms

September’s Editorial praises the new research that more genetic rodent models will enable. However, manipulating important genes in a mouse is not enough. Experimental techniques are also needed. Perhaps nowhere is this more important—and more difficult—than using animals to assess neuropsychiatric diseases. While much can be learned on the level of brain and cell physiology, behavioral tests are important to assess which aspects of physiology are most likely to matter. It’s the behavioral symptoms, not the cell-based ones, that directly affect people’s lives. How useful would a drug be if it cleared away the telltale plaques of Alzheimer’s patients but did nothing to preserve their memories?  Read more

Tags:

  • animal models
  • method development
  • mouse
  • neuroscience

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28 Apr 2011 | 12:00 PM

Efficiency through analysis

Posted by Daniel Evanko | Categories: Editorials, Nature Methods papers

The May Editorial in Nature Methods discusses how the overall efficiency of research can be improved by comparative analysis of research method and tool performance.  Read more

Tags:

  • analysis
  • method development

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