News Net

This week’s News Net brings bioentrepreneur news you may have missed from Spain, Pakistan and Florida. The stories highlight the role of government in encouraging the biotech sector—and the possible risks of doing so. How well does your government help to develop local biotech? Tell us in the comments.

 

  • A seminar for Spanish biomedical entrepreneurs was held earlier this month. Organized by the Fundación Rafael del Pino in Madrid, the event focused on investor involvement in biotech startups. Pedro Moneo, the director of Technology Review en español, said that “Globalization’s leaps are increasingly severe,” and added that if government itself does not act, “initiatives such as this one encourage competitiveness in the industry.” Read more here.
  • At another event, this time in Lahore, Pakistan, agriculture scientists, biotechnologists and farmers said that Pakistan desperately needs innovations like biotech to address challenges in agriculture to ensure sufficient food for a rapidly growing population. They urged the government to take concrete steps to bring improvement in country’s agriculture as it was imperative for economic growth of the country. More details from the Pakistan Observer.
  • In the US, the Orlando Sentinel reports on Florida’s almost $2 billion investment in biotech. Though critics are questioning the value of the investment, which includes matching funding from local governments, “Our eyes are still on the prize,” said Stephen Gardell, senior director of scientific resources at Sanford-Burnham Medical Research Institute at Lake Nona. Read the full article here.

Carving a Niche

The success story of Yosef Behrend suggests an unconventional, though seemingly straightforward way to create a biotechnology business.

In order to set up new companies, biotech entrepreneurs often look for groundbreaking technologies and unmet medical needs but Yosef Behrend has carved out a thriving  niche business in what is probably the oldest branch of biotechnology – fermentation.

Behrend decided to set up his own company, Fermentek, after studying and teaching industrial microbiology at the Hebrew University and working in R&D for the Sigma-Aldrich Corporation in Israel and the U.S. He  observed  that the commercial application of fermentation products  created by microorganisms was an underexploited field

Today Jerusalem-based Fermentek markets more than a hundred products – all based on biochemicals that Behrend and his staff have isolated and identified as having commercial applications.

Setting up the company was not expensive, Behrend explains, because he initiated his operations through conducting literature searches based on his expert knowledge of the microorganism field. He also saved on marketing expenses by establishing international distribution deals with leading companies like EMD Biosciences, Apollo Scientific, Enzo Lfie Sciences as well as  Sigma-Aldrich.

By pinpointing products not listed in the catalogues of the global biochemical providers, and by enabling the large companies to market his products under their name, Behrend worked out a win-win proposition for both sides. He has been able to leverage  the extensive sales forces of the international players, while  maintaining his own  independence and grow his business as he sees fit.

Currently Fermentek has 12 employees and more than $2.5 million in annual sales. The company is moving into new fields as it unveils a number of biochemicals with active pharmaceutical ingredients (APIs) that originate from microbial fermentation. Products being developed in collaboration with drug companies target oncological and dermatological indications for drug development.

Still, the main users of the antibiotics, enzyme inhibitors, ionophores, signal transduction agents, mycotoxins and other  biochemicals developed by Fermentek are researchers at life science companies, universities and government institutions.

Bernard Dichek

South Africa’s Pitch

South Africa recently claimed a victory. In May, it won the right to host the world’s biggest radio telescope. The $2 billion project, said Derek Hanekom, Deputy Minister of Science and Technology at BIO’s ‘The BRICS and Beyond’ special session (June 18) sent out a  sign that the country has left behind its troubled past and is ready for business. Beyond astronomy, and its azure skies, South Africa is a market poised for growth and a gateway to the rest of the continent. Continue reading

BIO: Day 1, and Turkey

Day 1 of BIO Convention.  The picture is from above the business partnering section of the conference, located alongside the exhibit hall.  Scores of rooms, and plenty of people putting them to use.  BIO offers many things – panel sessions, keynote speakers, receptions for mingling and, this year, the sights of Boston.  But much of the lasting benefit of BIO comes from those meeting rooms, where the drug discovery partnerships of tomorrow often begin.

I had a few (non-partnering) meetings of my own, but I managed to get in a quick panel session or two, including one from the international case studies track, exhaustingly titled, Transferring Know-How to the Market: How Have Current Changes in the Legislative Environment and Developments in Alternative Support Mechanisms Influenced R&D and Bio-Tech Activities in Turkey

Much of the presentation aimed to show the size of Turkey’s healthcare market. A Powerpoint slide titled “Investment opportunities,” detailed the recent and anticipated future spending on healthcare in Turkey.  In 2009, it was $39.9 billion.  That moved to $48.6 billion last year, and is expected to swell to $83.6 billion in 2016.  Turkey was billed as a “safe” location that provided access to Europe, Africa and Asia, and panel members pointed out that reimbursement isn’t much of a concern, as the government pays 85% of all drug bills.  All this, it’s assumed, might entice pharmaceutical companies to invest in Turkey via manufacturing facilities and distribution centers and the rest.

Turkey has growth goals, though, and the panel laid them out.  In 2011, Turkey was a net importer of pharmaceutical products, to the tune of $4.1 billion.  But by 2023, it hopes to be a net exporter, at $1 billion.  But where Turkey is lagging is in innovation, and that is the doorway through which walks both new benefits to patients, as well as the premium pricing those benefits can command.

The industry R&D spend in Turkey is just $50 million annually – in other words, about 1.5% of what Amgen spent on R&D in 2011: ~$3.2 billion.  The government invests more than $1 billion annually into academic research and startups through a program similar to the SBIR grants in the US, but with the expense of drug development, this number will have trouble powering the change Turkey is looking for.

Turkey knows this. While the “national desire” to become an innovator on the world’s biotech stage is there, said Gokhan S. Hotamisligil, panel moderator and the scientific founder of Syndexa Pharmaceuticals, the remaining challenge is “restructuring academia” to encourage it.

How that will be done wasn’t made clear, and it’s a Herculean task, one that can’t be completed simply with money and tax incentives (I’ve discussed this before while at BIO).  The good news is that Turkey isn’t sticking its head in the sand, and if Turkey wants to address that problem, the first step is recognizing there is a problem.

Brady Huggett

BIO Convention in Boston

Nature Biotechnology is again headed to the BIO Convention, happening June 18-21.  We’ll be posting to Trade Secrets while in attendance, as well as tweeting (@naturebiotech) on the #BIO2012 hashtag. Personally, I’ll be attending sessions that look at some of the more far-flung areas of biotech, and I’ve set up some one-on-one meetings that should be of interest to Trade Secrets, so I’ll pass along what I can.

Last year I posted some background on the BIO Convention itself before the conference began.  This year, let’s focus on the host city.

A recent census tells us the city covers about 48 square miles and more than 600,000 people within city limits, but that swells to above 4.5 million when including the Greater Boston area, ranking it 10th among US cities by population (or so says Wikipedia).  It’s a cold-weather city and can get pounded by blizzards, but the average June temperature is a quite comfortable 77° (F)

It has a strong history among the Irish, especially in Southie, and hosts a lively St. Patricks’ parade (they are already prepping for 2013).  It was home for the infamous gangster Whitey Bulger, recently nabbed by FBI but also dramatized on the big screen in Scorsese’s Oscar-winning film, The Departed.  Boston’s professional sports teams have represented the city well, with the Celtics last winning a title in 2008, the Red Sox in 2007, the Patriots in 2005 and the Bruins winning the Stanley Cup last year.

But most importantly for this blog, the Boston area is home to, arguably, the United State’s most vibrant biotech scene.  Data from Ernst & Young’s Beyond Borders report from 2011 show that New England biotech (consisting primarily of the Boston area) had 45 public companies in 2010, second only to the San Francisco Bay Area, with 65.  Though having 20 less companies, those New England firms had a combined higher market cap than the SF conglomerate ($63.6 billion vs. $58.6 billion) and just slightly less revenue ($12.4 billion vs. $13.5 billion). Walking through Cambridge means strolling by Genzyme, Biogen, the Massachusetts Institute of Technology and Harvard University.  It’s hallowed biotech ground.

Brady Huggett

The News Net

It’s time for a Net-ful of emerging biotech stories that you may have missed in the past few weeks. Happy weekend reading!

 

 

  • Via The Hindu, the Government of Karnataka has announced an expansion of its biotechnology finishing schools. The current 12 schools, which train graduates in skills required for the biotech industry, will be joined by new facilities in Rajasthan, Madhya Pradesh, Gujarat and Odisha. Previous graduates have all been placed in industry positions. More details here.
  • Sydney biotech Advanced Algal Technologies has signed a $100 million deal with China’s Fuzhou Xiangli Enterprise Management Consulting Co. Advanced Algal’s patented method of low-cost, high algal production process will be used to help reduce carbon dioxide emissions in manufacturing plants in China. Read more here.
  • Big Pharma is seeking to maximize its shrinking research budgets by looking at early-stage biotech, says Technology Review. Merck, Lilly and GSK, among others, have all invested in such companies recently. Here’s the the full article.

 

Minimum Requirement for a Successful Bioscience Ecosystem

I recently came across the book The New Players in Life Science Innovation by Tomasz Mroczkowski, in which he discusses the role of emerging economies in the global biosciences industry. Of course, in the topsy-turvy economic world we find ourselves in today, countries such as Brazil, China and India are taking leadership based, in part, on their growing economic strength.

How then would a small nation enter the biosciences industry as a novice? What would it need before it could start to develop its own indigenous biosciences industry? Is this even possible without the billions of dollars that is being spent by the aforementioned countries? Are there indeed minimal requirements necessary for the creation of a sustainable biosciences ecosystem, and, if so, what would they be?

If Mroczkowski had written his book 30 years ago, Singapore would have been given a whole section. In economic difficulties and with almost no bioscience infrastructure (although it had already started to make headway with textiles, fuel, and IT), Singapore was able to grow one of the most impressive bioscience ecosystems ever created, becoming a global industry leader with the highest per-capita gross domestic product in Asia outside Japan. The reasons for Singapore’s incredible success is the subject of heated debate, but two factors stand out – its proximity to large and growing markets (China, S. Korea, etc), and its early development of a government-backed bioscience ecosystem to support companies including services, manufactures and, critically, cash.

In large complex economies it is often easy to overlook the enormous advantages that are present simply as a factor of scale. Yes, some economies of scale are straightforward to understand, so it is obvious that the larger the internal market the easier and cheaper it is to reach, and therefore the better margins one can create.

However, as an entrepreneur within a small nation and part of a smaller internal market, the creation of a biosciences ecosystem from scratch is far from straightforward and forces the consideration of the different needs and attributes of bioscience companies.

Clearly, there are generic characteristics that apply to any ecosystem. The most important of these factors are simply “food”, “fuel”, and “space”. In economic terms and from the perspective of a dynamic, young ecosystem, which in my opinion still describes biosciences, then “food” describes a reliable supply of useable innovation; for “fuel” the ecosystem must have access to driving entrepreneurial energy deriving from innovative bioscientists as well as a constant supply of investment cash from biotech-savvy investors, and for “space” there needs to be a supportive environment, both political and economic, allowing embryonic ventures to grow and develop before being released into the economy.

However, these components of a nascent bioscience ecosystem on their own will only be able to maintain a self-limiting bioscience economy. To develop and sustain a high-growth, scalable, bioscience economy there must also be a reliable and economical route to global markets. This is a vital component that requires innovation in terms of business models and in terms of applying government assistance to reach external markets.

These six key factors are described in the simple diagram at the top of this post. In the proximity of these factors a new bioscience venture may at least be assured of a fair crack of the whip and will have a fighting chance, if their product is of sufficient quality and if there is a real need for whatever they are selling.

It is in everybody’s interest if our bioscience revolution continues to expand into more and more parts of our lives, and becomes a standard component of the economies of all countries. If this is to occur, then even current peripheral markets such as the Caribbean with 42 million consumers, or the many growing economies in Africa will need to find ways to build these ecosystems from the bottom up.

There is no reason to suppose that entrepreneurial energy is any less available in these new entrant countries than in today’s industry leaders.  Similarly, innovation is not simply a function of wealth and the size of the research base (although it is a very important advantage to have). So, assuming that the market’s appetite for bioscience products will continue to develop in these countries, as it will globally, the limiting factors may boil down to be political will, economic conditions, and access to start-up and development cash. All three can be influenced by government and all three can each be significantly affected by supportive fiscal policies and legislative structure.

Let us hope that as many of these smaller emerging countries as possible have a growing bioscience initiatives in their policies and have a clear view of what needs to be done to become the next Singapore.

Chris Hillier