Vaccines the world over

travel-around-the-world-1425331-639x958

Recently in an opinion piece in Authors Journal, I claimed that science is not popular. I said this because even though vaccines and antibiotics have greatly improved our health, most people do not understand that without them many of us would die before 40. The precise history of vaccines is difficult to know, but the concept is centuries old.

The second generation of vaccines was introduced by Louis Pasteur in the 1880s, who developed vaccines for chicken cholera and anthrax. During the 1900s vaccines became a matter of national prestige and compulsory vaccination laws were passed in Brazil. Yet vaccines were not easily accepted then or now. Oswaldo Cruz, a medical doctor, microbiologist and scientist was born in São Paulo-Brazil in 1872, studied two years in France. When he returned to Brazil he wanted to control outbreaks of smallpox, bubonic plague and yellow fever, but was opposed by Brazilian doctors, who did not believe mosquitos were the cause.

But the rise of smallpox in 1904 brought strong support of Rodrigues Alves, President of Brazil, and he decreed a forced vaccination. The reaction among the people against compulsory vaccination was strong, including dissent from the media, Congress and the Army, and what followed was a “vaccine revolt” that lasted in the streets for a week.

However, things changed. In 1907 yellow fever was fought in Brazil through vaccination and when small pox became epidemic in 1908 the population asked to be vaccinated. Oswaldo Cruz resigned some years later and died at 44 years in Petropolis. Today yellow fever still appears in Brazil. From December 2016 to May 2017, 792 cases were confirmed. So the disease has not truly been eradicated.

One might think that this is ancient history, but Italy and France had have faced measles outbreaks in recent years. The Italian Parliament last July 28th voted 296-92 in favor of a new law that will require parents to provide proof of vaccination against measles and nine other diseases, but  30% of Parliament voted against compulsory vaccination.

In France Prime Minister Edouard Philippe announced to the French Parliament on July 4 that childhood vaccines will be mandatory in 2018.He told Le Parisien previously that vaccination against 11 diseases were going to be demanded. Amongst 66 countries surveyed, the degree of confidence in vaccines suggested that the French populace was most concerned about vaccine safety. There are French and Italian parents who are hesitant or decidedly against vaccinating their children.

Science is not popular indeed.

Luiz Antonio Barreto de Castro

A new tool to study the immune system

mixr_crop

{credit}Irina D. Chudakova and Dmitriy M. Chudakov{/credit}

Beyond fighting infection, the immune system has important roles in many systems in the body. To study the involvement of T cells and B cells, researchers often sequence their T cell and B cell receptors (TCRs and BCRs), which provide insights into their clonal diversity. However, even more useful would be to gather T cell and B cell receptor information together with the transcriptomic profile of their tissue sample of origin. Now, in a paper published in Nature Biotechnology, Dmitriy Chudakov and colleagues report a software tool that enables extracting TCR and BCR sequences from bulk RNA-seq data sets. Because RNA-seq data is already available for thousands of tumor samples, this method will allow revisiting those data sets to extract important information.

Irene Jarchum

Bacteria to build materials

Tiny_things_resize

{credit}Yangxiaolu Cao {/credit}


Bacteria can be engineered to do all sort of useful things.  A field that is gaining traction is using bacteria to build materials made of organic and inorganic components. Writing in Nature Biotechnology, Lingchong You and colleagues develop an approach that uses synthetic biology to assemble materials in a programmable manner. The authors use self-assembling bacteria to generate inorganic-organic structures by applying gold nanoparticles to the bacterial colonies. The geometry of the bacterial-made structures can be changed by altering the characteristics of the membrane the bacteria are grown on (pore size and hydrophobicity). Using this approach, the researchers make pressure sensors (and provide accompanying video of the result).

A News and Views commentary from Neydis Moreno Morales and Megan McClean accompanies the paper.

Irene Jarchum

Insect resistance to transgenic crops

The pink bollworm rapidly evolved resistance to genetically engineered cotton in India, where ‘refuges’ of conventional host plants were scarce, but not in the USA, where growers planted planted non-Bt cotton refuges and suppressed this invasive caterpillar pest with mass releases of sterile moths.

The pink bollworm rapidly evolved resistance to genetically engineered cotton in India, where ‘refuges’ of conventional host plants were scarce, but not in the USA, where growers planted planted non-Bt cotton refuges and suppressed this invasive caterpillar pest with mass releases of sterile moths.{credit}Cara Gibson, University of Arizona.{/credit}

Farmers plant transgenic crops that produce insecticidal proteins from Bacillus thuringiensis (Bt) to combat destructive insect pests, such as the pink bollworm, that are capable of decimating yields. But resistant insects can overcome transgenic plant tech, potentially rendering transgenic crop lines obsolete.  How much of a problem is insect resistance to Bt transgenic crops around the world? Bruce Tabashnik and Yves Carrière review the global status of resistance of insects to transgenic crops producing insecticidal proteins from Bacillus thuringiensis (Bt) in the October issue of Nature Biotechnology. They extract the lessons learned from planting both single- and stacked-gene- insect-resistant Bt crops and consider tactics that could maintain transgenic crop efficacy in the future. The field data that inform this Review covers a large set of Bt toxins, crops and pest species, from 10 countries, on six continents.

Susan Jones