Post America Depression

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Leaving the bustling science scene in the United States can have its effects.

Dr. Shinya Yamanaka won the 2012 Nobel Prize for Physiology or Medicine, for his 2006-2007 work on induced pluripotent stem cells. I had a chance to hear him talk at the A*STAR Biopolis complex in April, where he gave a lecture on the recent progress in induced pluripotent stem (iPS) cell research. But at a smaller, 13-member session at Biopolis complex, he also spoke candidly with budding young scientists and junior faculty.

As I am about to start a tenure-track faculty position in Singapore, I asked Dr. Yamanaka what was the biggest challenge he faced as a junior tenure-track professor. He told me that after leaving San Francisco, where he’d made his big iPS discovery, and arriving in Japan, he suffered from “so-called PAD – Post America Depression.”

This was around 1999, and the scientific environment in the States was much better than in Japan, he said. In his lab at the Nara Institute of Science and Technology, he found he “couldn’t get good funding; I couldn’t get good support from other scientists.” And for the first three years, he couldn’t publish any papers. This eventually had him considering going back to the clinic, away from academic research.

Yamanaka said the scientific environment in Japan is “much better now, than 15 years ago when I came back.”  But he still advised that returning scientists keep good connections with the US, as “it is still clearly the center of science” and “most of the scientific papers are in the States.”  Keeping track of developments in the US helps motivate him, he said.

He had other bits of advice – don’t try to avoid mistakes, as they are part of the process; remember that running a lab is hard for everyone who does it – but I saw many heads nodding in agreement when he discussed his “PAD.” I also understand this, as I felt a palpable sense of loss when I left the labs at MIT where I had been for my Ph.D and post-doctoral training, and moved back to Singapore. I missed acutely my colleagues and collaborators at MIT, and I missed the atmosphere of urgency and innovation everywhere. This had me thinking this was more common that I had first thought, and I wondered if others have felt something similar.

Juliana Chan

BGI’s youth movement

mosaicPrior to meeting BGI Executive Director Dr. Wang Jun, I had been fascinated by the rise of BGI, the Chinese world leader in human, plant, and animal genetics research.

BGI began in 1999 as China’s representative to the International Human Genome Project, where it was responsible for 1% of the output. Since then, it has grown into a genomics powerhouse, making waves for its choice of projects, such as the BGI Cognitive Genetics Project, which is studying the genetic basis for intelligence, and its recent US$118 million acquisition of the California-based whole human genomic sequencing-technology company, Complete Genomics.

I met the 37-year-old executive director at the Plant and Animal Genome Conference (PAG) Asia that took place from March 17-19 in Singapore, and Dr. Wang explained to me how BGI was structured.

“We currently have 4,000-plus employees. BGI is divided into several parts. The first is BGI Research, which is doing a lot of academic non-profit research. Then we have BGI Tech, which is doing a lot of genomics and ‘omics services. Then we have BGI Healthcare, which is trying to deliver healthcare solutions to society. BGI Agriculture develops new breeds. We recently started a project to treat waste water to provide environmental protection. Those are the major parts,” he said.

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Interdisciplinary Research: Solution or Hype?

In the last week of January, I attended the Global Young Scientists Summit 2013, in Singapore. Modeled after the prestigious Lindau Nobel Laureates meeting held annually in Germany, the week-long Summit was organized by the Singapore National Research Foundation (NRF) under the theme of “Advancing Science, Creating Technologies for a Better World.”

About 280 invited post-doctoral fellows and PhDs attended talks, panel discussions and informal master classes. I spoke with Rendong Fang, a Ph.D. candidate in microbiology at KyotoUniversityin Japan, who studies the mechanisms of bacterial infection by Streptococcus pneumoniae. I also spoke to Andreas Braun, a computer scientist working at the Fraunhofer-Institut für Graphische Datenverarbeitung (Fraunhofer IGD) in Germany, who told me that ‘pervasive computing,’ where sensors and actuators are incorporated into the living environment, is the way of the future. Kelvin So, of the University of California, Berkeley, in the United States, told me he is working to use brain waves to remotely control prosthetic devices.

There were also participants from industry at the Summit, including Mingmin Wang, who graduated from Tsinghua University in 2007 and then joined GE Global Research in Shanghai, China, where he is now a lead scientist working on increasing the efficiency of solid oxide fuel cell (SOFC) systems.

The broad range of talent at the meeting was well paired with a discussion topic at one of the plenary sessions. Chaired by Prof. Bertil Andersson, President of the Nanyang Technological University of Singapore, the panel comprised Prof. Sir Anthony Leggett, 2003 Nobel Laureate in Physics; Prof. Hartmut Michel, 1988 Nobel Laureate in Chemistry; and Dr. Sir Richard Roberts, 1993 Nobel Laureate in Physiology or Medicine.

The panelists suggested that the boundaries between scientific disciplines are becoming less distinct, as scientists try to answer complex questions that require expertise from various fields. Andersson said that the borders between physics, biology, chemistry, earth sciences and the like are becoming “a little bit blurred,” and he said that major scientific challenges “probably need more than one expertise.” Michel, a biochemist, noted that he himself is “already interdisciplinary,” and suggested that science needed more mathematicians in biology in order to make use of all the data. And Roberts talked about his journey from childhood passion in mathematics to an undergraduate degree in chemistry, followed by a doctoral thesis in molecular biology and a career in bioinformatics.

It’s been a recent trend to mix disciplines and hope the results will solve some of science’s stickier problems. But is it possible the pendulum has swung too far? Leggett told the audience the term ‘interdisciplinarity’ is often “abused.”

“I don’t myself feel it is a good thing for government committees and so forth to encourage interdisciplinarity for its own sake. Some of these committees – at least in my experience – seem to be under the impression that interdisciplinarity is a sort of sauce, which you can put on otherwise unpromising ingredients, to improve the whole collection,” Prof. Leggett said. “I don’t really think that is right. The problem with that kind of approach is that sometimes people get the impression that simply to attack a problem in biology for the sake of attacking a problem in biology is itself a virtue.”

This raises a lot of questions. Is the term ‘interdisciplinary research’ an administrative label, describing scientific dilettantes without a core? Or should cross-boundary research always involve a team of researchers from various backgrounds? Should granting organizations do a better job of recognizing singular expertise?

And finally, does interdisciplinary research actually produce results?

Juliana M. Chan