Thinking about entering China now? Consider Why, How and Who

My first blog post noted that an increasing number of foreign bio-entrepreneurs are visiting China with the hope of finding money, and my follow-up explained why most of them are likely to be disappointed. But I also commented that if you want to understand the Chinese market, then it makes sense to start getting familiar with it now.

China will soon become the world’s second largest healthcare market, and in the long run, you simply cannot ignore it. But before jumping on the next flight to China, make sure that you can convince yourself why and how it’s crucial to act on your China plan now instead of later.

And I really do mean convince “yourself” — not just some potential investor — that it really makes sense to get involved in China now. For the reasons mentioned previously, if you are an early-stage biotech company, you may not be able to gain much money by visiting China. So you should have some other reason to think about getting into China now. And you should be very confident that you have the capability to actually execute your plan.

1. Don’t go just for the sake of finding money; go when it can actually give you a good current advantage or a strong anchor point.

I explained in my previous blogs that most early bio-ventures are unlikely to be able to gain much funding in China right now. So if you plan to be in China, you should have a compelling reason that goes far beyond just money. I have come across many business plans from overseas which contain a China angle — which isn’t surprising, because bio-entrepreneurs are well aware that this is essential in order to attract interest from China-based funds.

Of course, it’s not difficult to devise reasons why your long-term business case may involve China. At a minimum, multiplying the incidence rate of your target disease by the Chinese population base, you can probably derive a huge number of potential patients, which may get the VC very excited. However, trying to convince the VC is one thing — but making sure that you are convinced yourself is a completely different matter.

A good reason to begin investigating China now would be if this can give you a strong current advantage. For example, if your company makes medical devices that involve large volumes of labor-intensive manufacturing, then you might consider having this portion of the manufacturing process implemented in China — providing that you can do so without sacrificing on quality.

But even if you cannot find an immediate advantage to be in China, I think it may still be worth spending a year or two to explore the country, to learn about the market, and to see if you can find potential partnership or collaboration opportunities. These partnerships do not have to be commercial in nature —they can involve research collaboration with leading hospitals, or perhaps outsourcing some of your R&D work to an academic institution. China now boasts many clinical resources, including patient samples and very experienced doctors. If you can find a way to work with them, then you may gather valuable insights for your R&D, and you may also make friends and build relationships with key opinion leaders who will be able to help you navigate the complexities of the local market, when you do come to China for real sometime in the future.

2. Make sure you have strong local execution capability: hiring Chinese returnees may not be sufficient to guarantee that you can achieve your goals.

Having convinced yourself of the “why”, you must also convince of the “how and who” for carrying out your plan in China. From the outside, China may look like a relatively homogenous market; but in reality, there is considerable diversity across the country in terms of market conditions, the policy environment, and the characteristic local working styles. There are over thirty provinces and provincial-level cities, and most of them have similar populations and cultural complexities to a medium-to-large European country.

As a consequence, entering China is a big task. There are plenty of global-scale biotech companies who still do not have much presence in the country, such as Celgene or Gilead. So you should ask yourself, What are your goals, and how do you think you can maximize your chances of achieving them?

In my opinion, one of the key requirements for success in the China market is to have a strong execution team in place locally, and a firm commitment from headquarters to support the local management with considerable on-the-ground decision making. My experience has been that having “remote control” from headquarters, or “fly- in management” with periodic visits, simply does not work. You should plan to hire experienced local managers with strong execution capabilities and track records. Typically, such people have been in the China market doing a similar job in a relevant sector for several years.

Some bio-entrepreneurs have tried to short-circuit the challenges of identifying and hiring a strong local execution team by instead hiring a “returnee” — someone who is ethnically Chinese but who has lived and been educated abroad, so that they speak fluent Chinese and English, and are able to communicate easily with the firm’s headquarters back in North America or Europe. Admittedly, such people don’t suffer from the language barrier, which would affect a westerner arriving in China for the first time. But someone returning to China after more than five or six years outside the country are unlikely to be familiar with all the nuances of evolving local conditions.

My view is that if you really want to build up your capabilities in China, then you will need to invest time and energy into finding good people who can help you achieve your goals. You shouldn’t expect that you will be able to find them right away just by relying on help from headhunters. Instead, you should start exploring and learning about the market at a relatively early stage, so that you can begin to make contacts in your particular market niche —and by doing so, you will naturally get to know people who might become great recruits when you do start to build out your China capabilities.

(Karen Liu is a healthcare investor at a leading China based PE and VC fund. The views and opinions expressed here are entirely personal and may not represent those of her firm.)

Karen Liu

The Myths About Chinese Money for Your Startup

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As I mentioned in Part 1 of this series, foreign bio-entrepreneurs are increasingly coming to China to look for money. They come with two major misconceptions: First, they think there is plenty of VC money available for biotech startups; and second, they believe they can get free funding from the government and local bio-parks in China. Unfortunately, the reality can be far from their perception.

Myth #1: There is plenty of VC money available around China.

The truth is that at the moment, there is very little money available for early stage ventures, and even less for early stage bio-ventures at the moment.

VC/PE is indeed hot in China, and the market seems to be flush with money. However, most of the money is going to investment opportunities which are already at the PE/growth stage (read, “already showing profit”), or which can foresee an IPO within the next 2-3 years.

Many fund managers focusing on China self-describe as VC, but in reality are more like PE/late stage investors. This is especially true for the many RMB-denominated funds which tend to have a fund life no more than 4-5 years. There is very little money to support pre-revenue companies, or to fill the gap for the $2-10M Series A or B rounds.

To add to the challenge, while there may be over a thousand funds active in the market, there are probably no more than 20 funds seriously investing in healthcare and biotech, and only a subset of those will have an appetite for brand-new technology, which may take 5-8 years to commercialize.

Myth #2: You can get free funding from the government and local bio-parks.

The truth is that local bio-parks may be willing to provide land at low prices, and perhaps a period of free rental, for companies which are considered to be more “established” — but don’t count on the government for providing money required for working capital or R&D.

Various local governments have set up funds to support local technology development —but most of these are available only to local-based and locally registered companies. It is possible to set up a local operation in order to qualify for these funds, but the direct cost of doing so, plus the indirect cost associated with additional management complexity, may end up being greater than the amount of money that you can gain.

Many local bio-parks have a window of only 3 to 5 years in order to prove their success with economic results, such as being able to show evidence that their tenants are generating tax revenue for the local government, or at least demonstrating that they have been able to attract high-talent employees to their park. Consequently, they too are under severe time pressure.

My observation has been that during the first couple of years after their launch, many local bio-parks are willing to provide some free support — but the bio-park may not have complete infrastructure during that period, so effectively you are getting partial compensation for the “hardship”.

Moreover, if your firm is still at the stage of proving its technology, then your product development cycle may be longer than the tenure of the local party leadership — and if so, then chances are that you will not get more than a few months of free rent. (And as noted above, it’s likely that you will have had to spend some money up front anyway, in order to establish the local branch operation which was a prerequisite to obtain local funding.)

Sounds depressing? Well, the outlook for early-stage funding is actually starting to improve. As I noted above, the majority of VC/PE funds are still focusing on investment opportunities which offer the prospect of quick gains. However, as competition heats up for those late-stage deals, it seems likely that a considerable amount of money will likely spill over toward early-stage ventures.

Over the past couple of years, healthcare and biotech opportunities in China have started to receive a lot more attention from VC/PE firms. So even though there are still only a few active bio-investors, the number of potential funding sources is clearly starting to increase.

Moreover, Chinese pharma companies and biotech entrepreneurs are also increasingly hungry to get involved in great new technologies, and also to develop partnership opportunities with their counterparts in the West. China always changes at a speed which surprises people, and I believe that in a few years, or possibly sooner, there might be a lot more funding sources for early-stage biotech ventures.

So in a few years, if your company is lucky to live till then, there’s a good chance that you will be better received in China than today. But if you are thinking about building a China footprint in the future, it’s not too early to start exploring — as long as you have plenty of patience, and set appropriate expectations. For the reasons given above, you may not find money right away — but if you are lucky, you will make some good friends, some useful connections, and some potential business partners.

My next blog post will provide some initial advice for bio-entrepreneurs who are planning to visit China in order to start getting familiar with the environment.

(Karen Liu is a healthcare investor at a leading China based PE and VC fund. The views and opinions expressed here are entirely personal and may not represent those of her firm.)

Karen Liu

Looking for China money for your biotech venture?

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While vacationing in the US during the Chinese New Year

early February, I attended a Bay Area event organized for VCs (venture

capitalists) and medical device entrepreneurs. I was a bit surprised by the

sentiment voiced by the panelists and the audience that “there is plenty of

venture money available in China”

and “given the tough funding environment in the US,

companies should look to China

for alternative sources of venture money”. “Aren’t the roads there paved with

gold?” a Chief Medical Officer for a Bay Area biotech startup jokingly asked

me. As an active healthcare VC in China in the past few years, I know

this view is far from accurate.

It is not hard to understand why investors and entrepreneurs

might view China

as a bountiful source of financing. At the end of 2010, China held over

$2.8 trillion of forex reserves. The Chinese government has played white knight

in an effort to help stabilize the Euro zone economy, by buying

euro-denominated Portuguese and Spanish debt. These facts have been widely

reported in the US press,

and I’m sure that US biotech entrepreneurs have also heard about the

hyper-active PE (private equity) and VC industries in China.

There is no comprehensive list of all the PE and VC funds with

a focus on China

who are actively investing. However, there are probably over a thousand of

these funds, and it is quite possible that more than half of them probably

raised fresh money over just the past two years. Statistics from ChinaVenture

suggest that such funds raised more than $12.3 billion in 2009, and over $30

billion in 2010 alone.

Moreover, the Chinese government’s 11th and 12th

five-year development plan spanning from 2006-2015 places a high priority on

biotech. As a result, dedicated central government funds have been allotted to

incentivize new drug development, and dozens of biotech parks have sprouted

around major cities to support biotech companies.

So is China

a good place for your biotech startup to look for money? Think again!

Over the past two years, I have come across a fair number of

entrepreneurs from North America and Europe,

with deals ranging from pre-clinical or phase I/II therapeutics to

prototype-stage medical devices. Many of these entrepreneurs had included some

sort of China-related story in their business plan. But most of them have

ultimately not been able to implement the Chinese dimension of their plan, even

after half a dozen trips to China

and many meetings with local investors and bio-parks. As a consequence, they

have left the country empty-handed — though after a series of eye-opening

experiences, and probably a sense of repletion after several elaborate banquets.

So the people I met at the Bay Area event are not so very

different from many bio-entrepreneurs who came to China with high hopes but major

misconceptions. Many of them appear to believe that: 1) there is plenty of VC

money available around China

for biotech startups; and 2) startups can get free funding from the government

and local bio-parks.

Unfortunately, I can tell you that if you are a starving

early stage biotech startup, chances are slim for you to get funded in China.

In next blog post, I’ll be explaining why.

(Karen Liu is a healthcare investor at a leading China based PE

and VC fund. The views and opinions expressed here are entirely personal and may

not represent those of her firm.)

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Karen Liu