Some science and some serendipity

What at first looks like a setback may be an opportunity in disguise, says Flavia Scialpi

I keep my business cards in the top drawer of my desk at work. They are in two bulky boxes and take up a lot of space, but I like them there because I can see them every time I pull out a pen. They are a memento of how very often you can’t foresee where an opportunity lies – and therefore to seize each and every one of them.

I have been in academia for almost half my life, and I am now engaged in my first position in industry at Synpromics, a biotech company. It is the first time in my professional career that I hold a position that requires and provides business cards.

New Accomodation at Roslin Innovation Centre

Scialpi’s new Accomodation at Roslin Innovation Centre

A few years ago I thought I wouldn’t have any chance to land a job in industry. Nor was I very interested in it, to be honest; I was content with academic research, greatly enjoying the highs and bitterly venting about the lows. I went for a well-trodden path; I got my PhD in Italy, where I’m from, and then ventured abroad for a postdoc. I felt the world was my oyster and I found a second home in beautiful Scotland. Continue reading

The competition that likes to say YES!

Enterprising early career researchers get some high-level mentoring to handle the rough and tumble of the boardroom. David Payne meets finalists in the 21st annual Young Entrepreneurs Scheme (YES)

Epitome is a Singapore biotech start-up whose product pipeline is based on engineered tail proteins to tackle bacterial diseases. It wants a slice of the US’s $6bn acne market. Epitome’s founders are seeking raise $10m to build a factory where its cosmetic products can be manufactured. Investors will be rewarded with a seat on its board.

The launch team describe the company at a presentation attended by other young entrepreneurs. They brace themselves for some tough questions from a judging panel. One judge asks how a factory can be built for $10m Another challenges the team’s plan to launch an acne treatment as a cosmetic product, which means they won’t mention acne on the label (the team adopted this approach to make the US regulatory process more straightforward).

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‎Elena Lurieluke, Head of Global Life Sciences Open Innovation, Corporate R&D at P&G, addresses fellow YES judges and finalists.

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‘Myth Breaker’ review

When fellow science journalist Seema Singh’s book ‘Myth Breaker’ with a gleaming cover portrait of India’s best known biotech entrepreneur Kiran Mazumdar-Shaw landed on my desk, I was slightly sceptical of the contents. Another glossy biography, I thought to myself. A few pages into it and I was forced to change my mind. Here’s why.

(Reproducing a review of ‘Myth Breaker’ written on invitation by a national business daily.)

New Picture (1)The irreverent entrepreneur

As a young reporter interested in India’s so-called biotech boom around the turn of the millennium, I was putting together a wish list of people to meet in Bangalore, the biotech boom town. And Kiran Mazumdar-Shaw’s name was obviously on top.

The newsroom had some interesting observations to offer when they heard the name: “Meeting the Czarina of India biotech, are we?” asked an informed colleague cheekily. “Quiz her well on the regulations — a lot that’s gone wrong in the sector is being attributed to her,” said another.

My meeting with Mazumdar-Shaw was cordial, sprinkled in good measure with her signature eye-smiles, despite some not-so-comfortable questions.

Among other things, I remember talking at length about Biocon’s newfound interest in monoclonal antibodies. Back in the newsroom though, the questions from colleagues lingered. “Was she tough?”, “She’s known to keep people waiting, did she?”, “Did she yield?” And some other unrelated curiosities.

That was indication enough — even with my fledgling journalistic acumen — that the woman was making a difference, raising eyebrows, marking a strong presence in India’s biotech sector.

A rare persona

Seema Singh’s book brings to life this brazenly confident woman — a tough negotiator, a tenacious fighter, a fierce protector of her company values and employees and the loudest voice today of India’s biotech sector. In ‘Myth Breaker’, Kiran Mazumdar-Shaw, comes across as a rare workaholic entrepreneur who rules the boardroom and, with equal ease, doesn’t spare a thought to take a month off and attend to her cancer-stricken husband in a London hospital.

‘Myth Breaker’ is also a well researched story of India’s biological sciences research, of the many enterprising and gutsy scientists who have made this landscape a breeding ground of innovation. Of failed experiments, scientists’ resentments with grant-giving agencies, of the birth of the biology boom.

And of interesting stories behind setting up of India’s Department of Biotechnology and pioneering laboratories such as the Centre for Cellular and Molecular Biology, the Centre of DNA Fingerprinting and Diagnostics, the National Centre for Biological Sciences, and the Institute of Genomics & Integrative Biology.

The narrative is woven around the biotechnology revolution that Mazumdar-Shaw spawned 10 years before the Indian government thought of creating a department of biotechnology. Singh aptly points to the rude reality that policy following entrepreneurship by a decade is ‘hara-kiri’ for a nation.

The buzzword in India’s science today is jugaad or frugal innovation — a concept being borrowed for optimum use of resources across the science-faring world. Mazumdar-Shaw and her aides used these very tools 40 years back to build capacity, acquire talent, innovate and escalate — adding one proverbial brick at a time to build the $ 1.5 billion Biocon empire. Going from enzymes to biopharmaceuticals, the company has been a trendsetter in sticking to biology-led innovations while many others gave in to the lure of pharma molecules and generics.

All this, obviously, was not achieved without hiccups and heartburns, tantrums and ego fights among employees — the book lays bare some of those interesting stories as well.

Spirit of resentment

Singh, an ace science and business journalist, took almost a year of digging for the back stories — travelling and interviewing scores of people who came on board, left midway or were laterally involved in the making of Biocon.

She meticulously Skyped up key overseas characters in the story (no email interviews, she insisted) to get an idea of the people in question and also to keep a record of what is essentially an oral history. “I had no idea that they had built all of this, it was only when I started writing that I figured how big it was,” she says. The book also gives much space to the innards of Biocon — its making and merging, crawling and grunting, preening and rumbling – which might be of interest to industry watchers, not necessarily to a lay reader. Singh says it was not meant to be an academic read, neither was it meant for everyone — its readership is select, by design.

One of my favourite bits from the book, however, is where Mazumdar-Shaw is at her cheekiest, tactless best. Unilever bought Biocon in 1989 and a large delegation of Unilever top shots descended in Bangalore to convince her to dilute stakes in the Indian operation.

Mazumdar-Shaw’s first slide during her presentation to this delegation said,” There are three types of companies: 1. Companies which make things happen; 2. Companies which watch things happen; 3. Companies which wonder what happened. Biocon India is the first type of company and Unilever is the third type.”

At 63, Mazumdar-Shaw continues to take on her detractors head on, sometimes tactfully, most times with this signature impertinence. Even on Twitter, where she fights off each and every troll zealously. And shoots out impassioned appeals to the powers in Delhi, time and again, to make life easier for biotech entrepreneurs in this country. She has minced no words on social media asking for a change in government policies to make it easier to ‘Make in India’.

Surviving the murky world of corporate acquisitions and bullying, she continues to uphold the spirit of resentment.

Singh captures this plucky woman’s journey well, giving us a parallel peak into the contemporary history of biological sciences in India.

Seema Singh is a journalist. Until 2013, she was a senior editor with Forbes (India). She has also written for publications such a The Times of India, Mint, IEEE-Spectrum, Red Herring, Cell, New Scientist and others. Singh has been a Knight Science Journalism Fellow at Massachusetts Institute of Technology and a MacArthur Foundation research grantee.

London’s biotech hub with Kit Malthouse

Is London ready to become the next biotech hub?

Kit Malthouse

{credit}Hannah Lucy Jones{/credit}

In this month’s Windback Wednesday series, we’re all about entrepreneurship: what it takes to be one, how to become one and more. But if you’re based in London, it’s not so easy. Although it’s got the brains and research centres to make it a hub, setting up shop in London is the tricky part. In this podcast, I speak to Kit Malthouse, the Deputy Mayor of London for Business and Enterprise, and find out how London is preparing to become the next biotech hub.

Kit Malthouse, the Deputy Mayor of London for Business and Enterprise has big plans for London. In his speech at SynBioBeta event at Imperial College London, he spoke of his dreams of London becoming the next big hub for biotech start-ups. He is aware that the foundations for this already exist.

“To a certain extent we already are. We have a huge life sciences sector.” Five large research institutes, many hospitals, Institute for Cancer Research the Crick Institute (soon!) and many more are part of an ecosystem that already exists in London. But what the Deputy Mayor hopes to do is “give it some coherence, so that it comes together as an entity… promote it, and fundamentally attract investment in.” 

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The biotech industry with Rob Carlson

Rob Carlson

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In this interview, I speak to Dr. Rob Carlson, a Principal at Biodesic, an engineering and strategic consulting firm in Seattle that provides services to governments and corporations around the globe. At the broadest level, Dr. Carlson is interested in the future role of biology as a human technology. He is the author of the book Biology is Technology: The Promise, Peril, and New Business of Engineering Life, published in 2010 by Harvard University Press; it received the PROSE award for the Best Engineering and Technology Book of 2010 and was named to the Best Books of 2010 lists by writers at both The Economist and ForeignPolicy.com. Carlson is a frequent international speaker and has served as an advisor to such diverse organisations as The Hastings Center, the PICNIC Design Festival, the UN, the OECD, the US Government, and companies ranging in size from start-ups to members of the Fortune 100. Carlson earned a doctorate in Physics from Princeton University in 1997.

How did you move into the industrial world of biotech?

I followed my nose. My formal education is in physics, with some neurobiology and electrical engineering thrown in. I spent a number of years labouring under the expectations of my professors that I would eventually become a professor, too. Continue reading

From industry to academia with Sterghios Moschos

In this podcast, Naturejobs interviews Sterghios Moschos, reader in Industrial Biotechnology and Biochemistry at the University of Westminster in London. We talk about his transition from industry back into academia, and the different attitudes to science that he has experienced.

You can now subscribe to the RSS feed or to our iTunes channel! Continue reading

Cambridge start-up named in university/hospital cancer patent lawsuit

From the Globe:

A nonprofit cancer research institute has sued a Cambridge biotechnology company and one of its cofounders for more than $1 billion, alleging they took intellectual property developed at the institute and used it to launch a for-profit business.

The Leonard and Madlyn Abramson Family Cancer Research Institute, part of the Abramson Cancer Center at the University of Pennsylvania, contends in the lawsuit that Dr. Craig B. Thompson and Agios Pharmaceuticals Inc. are developing drugs to suppress cancer cells’ ability to grow and reproduce, based on novel research conducted during Thompson’s tenure as leader of the institute.

AAAS offers more including a link to a .pdf of the complaint.

The complaint says that Thompson was at first forthcoming about the possibility that he would form a company based on his work in cancer cell metabolism. Among other things, in 2007 he reported that his work suggested that the diabetes drug metformin might reduce the risk of cancer. But, the complaint continues, he did not alert the institute when he helped launch a company in August of 2007, which was later renamed Agios Pharmaceuticals.

Still, the lawsuit doesn’t state that Agios was willfully hiding the fact that Thompson was a co-founder. In 2009, the complaint notes, the company stated publicly that Thompson was one of three founders. A search of Agios’s press releases also found that the first put out by the company in 2008 list Thompson as a co-founder.

But the complaint alleges that Abramson didn’t know this at the time. In October 2011, it was publicly reported that Celgene was investing another $20 million in Agios on top of $130 million invested in April 2010. The April 2010 Agios press release announcing the deal did not name Thompson as a co-founder, the suit says.

And from Pharmalot:

Disputes over the origins and ownership of potentially valuable medical research happen regularly, although not every episode involves the ceo of a high-profile institution. For this reason, the spat may be more closely watched than most, especially given the prominence that Memorial Sloan-Kettering has among the elite in New York.

We asked Thompson for comment, but have not received a response and will update you accordingly. An Agios spokesman writes us to say that the drugmaker is “aware of the stories that are circulating, but the company has not formally been served with any legal documentation. Agios always has and will continue to operate with the highest level of integrity. We will not be commenting on this litigation further at this time.”