Scientific play is a serious business

Iva Njunjić’s dream to explore caves and work on cave beetles took her far from her home country of Serbia — to the beautiful island of Borneo.

Bod Tai cave on Borneo-smaller

This photo was taken during field work in Sabah, Malaysia where Prof. Menno Schilthuizen, his PhD student Mohd Zacaery bin Khalik and I went to explore caves and hunt for new species of cave invertebrates. We spent many days around a small village on the Kinabatangan River, trying to locate caves in numerous limestone hills and gather information about the organisms that live there. Continue reading

Reflections on the L’Oreal-UNESCO For Women in Science program

Muireann Irish on celebrating diversity in science

Springtime in Paris seems a fitting backdrop for any awards ceremony but particularly so in the case of the L’Oréal-UNESCO For Women in Science program. I recently had the honour of attending the 2017 International Awards along with 14 other early career researchers from around the globe, as part of the L’Oréal-UNESCO International Rising Talents Fellowship.

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Visual experiments straddling art and science

Filmmaker Markos Kay.

Filmmaker Markos Kay.{credit}courtesy of Eliza McNitt{/credit}

Digital artist and director Markos Kay pioneers at visualising the unvisualisable.

“Art and science are drivers of cultures,” says Kay, who visited the Middle East for the first time last month to exhibit a new film called ‘Quantum Fluctuations: Experiments in Flux’ at the Imagine Science Film Festival in Abu Dhabi. “I want to challenge our ideas of how our knowledge of reality is formed.”

He is perhaps best known for a generative short called The Flow (2011), which was featured in an episode of the TV hit series Breaking Bad.

The Flow takes its audience inside a proton, with the aid of simulation software and algorithms, to see a dramatically-visualised interplay of quarks and electrons, resulting in nuclei and atoms. “I was really frustrated that nobody is trying to visualise all this in a more accurate way, so I tried to make my own film. I wanted to show people how complex this stuff is,” he says.

Kay’s work explores and abstracts the complex worlds of molecular biology and particle physics, be it through presenting a different way of observing cells or using the visual language of a microscope to give life to an organic process. “The desire of an artist to find ways to interpret and observe the world is similar to a scientist’s,” he says of his own experiments.

A still from Quantum Fluctuations.

A still from Quantum Fluctuations.{credit}Markos Kay{/credit}

His films are usually filled with detail and movement, and often feature scores of orchestral sounds or a generative, organic soundscape created by algorithm-based software.

His new film, ‘Quantum Fluctuations’, for instance, meditates on the transient nature of the quantum world which, he says, is impossible to observe directly. The film re-imagines the complex interactions of elementary particles as they collide inside the Large Hadron Collider at CERN –– and it’s all presented against a musical backdrop that is designed by Kay himself. Through striking computer-generated imagery, we can see interactions that occur in the background of a collision; for example, particle showers that erupt from proton beams colliding, giving birth to composite particles that eventually decay.

“Since the time of Heisenberg, it’s been almost impossible to visualise these events and simulations. It felt like a challenge,” Kay says. The film was produced by experimental design studio Epoche.io and will be part of an art and science documentary called “Sense of beauty” that focuses on CERN’s particle physics and that will be released later this year.

His latest project Humans After all, in collaboration with photographer Jan Kriwol depicts people in the context of everyday life through their circulatory systems. The project that showcases its subjects – humans stripped down to blood vessels and neural circuits – in an urban setting is meant to highlight the fragility and vitality of the human body.

“Through my work, I try to create immersive environments so that people can feel they’re entering a distant world.”

Humans Afterall.

Humans Afterall.{credit}Markos Kay / Jan Kriwol{/credit}

New neuroscience tools for team science in ‘big data’ era

By Esther Landhuis

Wandering the convention center among 30,000-plus researchers, students and vendors at the Society for Neuroscience annual meeting in San Diego last November, I struggled to wrap my head around a feature I was writing for this week’s Nature, on managing big brain data. Mice, molecular biology and cell sorting reigned supreme in my former life as a bench scientist. Neurons, brain imaging, terabytes — not so much. So when it came time to find an entry into the vast universe of the brain, I latched onto something that seemed small and manageable: the fruit fly.

Ann-Shyn Chiang of National Tsing Hua University, Taiwan, told the SFN crowd his team has spent a decade imaging 60,000 neurons in the Drosophila brain. The pictures produced 3D maps detailed enough to show which neurons control precise behaviors, such as shaking the head side to side (see video). But here’s the part that blew my mind: They aren’t even halfway done (flies have 135,000 brain neurons), and mapping the human brain with similar methods would take 17 million years!

Head shake behavior elicited by a 593.5-nm laser. Credit Po-Yen Hsiao and Ann-Shyn Chiang.

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You’re a designer — act like one

To communicate effectively, scientists have to start thinking like designers: know your audience, follow the rules of human perception, and tell your story in many layers.

Naturejobs journalism competition winner Lev Tankelevitch

This past August, I visited the Naturejobs career expo in London. As I chatted with exhibitors, I was ready to decline the typical set of leaflets they give away at these things. To my surprise, I was given a USB stick loaded with all of the information that I’d otherwise be carrying home in a canvas bag. This small but much appreciated gesture highlighted for me the significance of effective communication.

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Finding job satisfaction as a drug safety manager

Steffen Schulz was completing his PhD in medical neuroscience when he realised he needed more job security than academia could offer. Now, he works as a drug safety manager in his native Berlin.

How did you get into biology?

Originally I was interested in the origin and the development and evolution of life. Then I shifted to questions like ‘why do animals and humans behave the way they do?’

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Steffen Schulz

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Study system envy

Graduate students must often weigh the pros and cons of straying from an advisor’s research program

Guest contributor Carolyn Beans

Early in graduate school, I had total study system envy. In many biological fields, including my own field of evolutionary ecology, a study system is a specific species that a scientist uses to run tests. Some of these species like mice, zebrafish, and the plant Arabidopsis are model organisms, and have been well-studied for decades or more. Whether scientists choose a model organism or a relatively unknown species as a study system can have drastic consequences for their research.

Zebrafish

Zebrafish{credit}Uri Manor, NICHD{/credit}

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#Scidata15: Big data: Challenges create opportunities

The era of big data brings with it a sea of opportunities for development and innovation.

Guest contributor Daniela Quaglia

naturejobs-blog-Scidata15-Opportunities-from-Research-Data

{credit}Image credit: SCIENTIFIC DATA/LUDIC GROUP{/credit}

Big data is here to stay. As scientists, we stand to benefit by being part of this exciting revolution. At the second Publishing Better Science through Better Data conference, held in London on October 23rd, Dr. Ewan Birney, joint associate director of the European Bioinformatics Institute (EBI), and Dr. Timo Hannay, founder of SchoolDash (a website that provides statistics about schools in England), walked us through some of the opportunities that arise from working with big data.

Opportunities in biology

Birney spoke about how the increase in big data is influencing the way we do biology. He promised to give the audience “an EBI centric view of the world”. I’m glad he did, because every scientist wanting to use big data should understand how EBI can help them.

EBI takes data provided by laboratories and stores, verifies, classifies and shares it. This approach means that a wealth of molecular-biology data, from DNA sequences to full systems (such us biomolecular pathways and metabolomics data), can be found in one place. As most scientists do not want to have to work from shared data in their raw form, the institute also works with the scientific community to convert original data into useful formats. Data from the Human Genome Project provides a compelling example of how such transformations can benefit the community — as Birney pointed out, not even the most experienced researchers want to analyse such complex raw data. Continue reading

Most read on Naturejobs: October 2015

Career uncertainty, industrial postdocs, writing for highly-selective journals and more!

naturejobs-readsThank you to everyone for reading our posts this month. We’ve been working closely with a lot of new writers, and we’re pleased that you’ve enjoyed what they have to say! Here’s a list of your top ten favourite reads from October.

This year Nature have been running their Graduate Student Survey, trying to understand what careers graduates are looking to do when they finish their training, and how they are preparing for them. In Graduate survey: Uncertain futures, Chris Woolston gives a great summary of the results, and shares some stories from graduate students around the world.

Industrial postdocs: A bridge between two worlds is a report from the Naturejobs Career Expo in London earlier this year, where Roche presented a workshop on the postdoctoral opportunities they offer.

The traditional route in academia – PhD, a postdoc or two (or three) and then professor – is one everyone is familiar with. But there are other options, as Careers in academia: Different options explores. This is another report from the 2015 Naturejobs Career Expo in London, where different types of academics gave an insight into their different roles.

The Naturejobs Career Expo reports are popular this month! Nature Masterclasses: Writing for highly-selective journals, is another report from the event, this time about one of the workshops run by the Nature Masterclasses team. Continue reading

Data sharing: Fewer experiments, more knowledge

Data sharing will reduce the experiments needed in the lab and will increase the speed of knowledge generation by decreasing the time spent on the generation of equivalent datasets.

Guest contributor Ana Sofia Figueiredo

biological-model-naturejobs-blogI’m a postdoctoral scientist in systems biology at the University of Magdeburg, Germany. There, I build mathematical models to understand the mechanisms behind certain biological processes, such as the process of energy production by cells under extreme conditions. These mathematical models are representations of reality and some of them can be useful, although all of them are wrong. When well parameterized with data, these models give a quantitative representation and better understanding of such biological processes. Using a systems biology approach, I can do experiments in silico that are very difficult or technically impossible to do in vitro or in vivo.  However, a model is only as good as the data it incorporates.

When I have access to publicly available experimental datasets, I can plug the data into my models and, from the synergy of combining mathematical models with experimental data, learn more about the biological system I have at hands.

Sharing data, models and experimental protocols can push forward the generation of knowledge in science. Continue reading