The Daily Dose – The stem cell vetting continues

US National Institutes of Health (NIH) director Francis Collins yesterday announced the addition of eight new human embryonic stem cells lines to the NIH’s registry, bringing up the total number of stem cell lines available for use in federally funded research to 75. The new lines were developed at the University of Connecticut, the University of New South Wales in Australia, the Whitehead Institute for Biomedical Research, and Advanced Cell Technology, a Santa Monica biotech company.

But Collins rejected 47 lines that were submitted by the Reproductive Genetics Institute in Chicago, saying that language in the consent forms was “inconsistent with the basic ethical principle of voluntary consent” because donors waived all rights to sue the clinic for any reason. The repudiation comes as a blow to many researchers, since the Chicago lines are known to carry mutations for a range of diseases from cystic fibrosis to muscular dystrophy.

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A Daily Dose from ISSCR 2010: Tales from the crypt

Three years ago, Hans Clevers at his colleagues at the Hubrecht Institute in the Netherlands discovered that a unique molecular marker called Lgr5 singled out stem cells in the mammalian intestine. Reporting yesterday at the International Society for Stem Cell Research meeting in San Francisco, Clevers claimed he can now expand these stem cells to grow as much intestinal tissue as needed for transplantation — and all without genetically altering the cells. “This would open a very classical way of regenerative medicine,” he said at a press conference.

Here’s a video from Clevers’ lab describing the crypt-ic stem cells:

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