The Daily Dose – A feast that’s fat for the gods

2149312640_e3b3b65125.jpg

— Short hairpin RNA molecules were able to block the production of the CCR-5 receptor in mice engineered to possess human immune cells, pointing to a possible therapy against HIV/AIDS in the future. People who lack this CCR-5 receptor on their cells seem to have natural resistance to HIV, but this mutation is extremely rare.

– According to a case report, an adolescent girl was infected with rabies last year, but survived without intensive care. There are a couple caveats – including that she tested positive for virus-neutralizing antibodies only after being given the rabies vaccine — but despite this first-of-its-kind case, experts stress that rabies remains highly dangerous.

— The next step toward an electronic network for US healthcare? It’s in the Department of Justice and Homeland Security, apparently. The Office of the National Coordinator for Health IT reportedly plans to use one of the department’s information exchange networks as a testing ground for its Nationwide Health Information Network. (GovHealthIT)

— Walk like an Egyptian, but please don’t eat like one. Researchers say that the lavish banquets ancient Egyptian priests offered the gods were full of food with high fat content. The priests also brought the food home to their families, and an analysis of 16 mummies found that nine had evidence of clogged arteries. (BBC)

Image by upyernoz via Flickr Creative Commons

An ounce of common fund is worth a pound of new programs

Hot on the heels of yesterday’s announcement that the US National Institutes of Health (NIH) was teaming up with the Food and Drug Administration to conduct research into the drug approval process, the agency today rolled out six more initiatives to foster collaborative research across the various NIH institutes and centers.

Among the new programs, which are supported by the NIH Common Fund to the tune of $17.8 million, is a new center for studying induced pluripotent stem cells and an effort to phenotypically characterize thousands of knock-out mouse models.

“These strategic investments will yield critical new resources, scientific knowledge, and strategic partnerships across a broad landscape of basic biology, behavioral science, global health, and clinical medicine,” said NIH director Francis Collins in a statement.

The remaining scientific programs include research tools for studying proteins, an examination of how biology, culture and society together affect people’s behavior, a new global health program, and a systems biology resource called the Library of Integrated Network-based Cellular Signatures, or LINCS.

The Daily Dose – The appeal of a repeal

gavel2.jpg

— There are plenty of questions of trust today in Washington, DC, as the President’s health care summit goes live. Yesterday, however, at least one was answered: The House voted overwhelmingly to repeal an exemption from antitrust laws for health insurance companies. The exemption had been in place since the end of World War II. (CNN)

– The addiction researcher accused of fabricating data – and hiring actors to clear his name — was reportedly found dead in his home on Tuesday. William Fals-Stewart, a former University of Buffalo professor, faced new charges last week for false testimony provided in his 2008 fabrication case; a conviction could have yielded him 15 years in prison. (Buffalo News)

— Pharma is hoping that customers will follow their peers. Several companies are finding that peer-influence marketing, which uses testimonials and advice from real people, is the way of the future. Eight of the top 50 selling drugs have ads featuring real users, and that’s expected to increase as companies abandon celebrity endorsements and other methods. (WSJ)

– Animal rights activists are going after more than just researchers, now – they’re going after researchers’ children, too. Activists are planning to leaflet the school campus of a neurobiologist’s son, educating classmates on his father’s non-human primate research. (LAist)

Image by walknboston via Flickr Creative Commons

The Daily Dose – Flu virus gene shuffle proves fatal

CardShuffle.jpg

— The US National Institutes of Health and the Food and Drug Administration announced today a partnership to advance regulatory science and better integrate the drug research and approval processes. The three-year initiative includes the creation of a joint council and a public hearing this spring on how the FDA and NIH can bring safer products to market sooner.

— Researchers have developed a new method for detecting whether drug candidates hit their targets. The process, called ‘microscale thermophoresis’, registers the energy released when two compounds combine to determine the binding effectiveness of a drug candidate. The creators of the test say it can be performed in blood samples, not just buffer solutions.

— Pull out the Purell and slide on your surgical masks. Well, not really. Scientists have created three new virulent strains of flu in test tubes. Genes were shuffled between avian and seasonal strains, yielding more than 250 combinations. When these strains were tested among mice, 22 proved more easily transmittable than seasonal flu, and three of these were also more fatal. (Reuters)

— Scientists have found that a human protein implicated in cancer can also revive dying arabidopsis plants. The protein, insulin responsive aminopeptidase (IRAP), is a human analog of aminopeptidase M1 (APM1), which contributes to root development in plants. Lab animals, hold back your squeaks of celebration, but according to the authors of this study, arabidopsis might prove to be a plant model for cancer. (ScienceDaily)

Image by .:Axis Theory Photos:. via Flickr Creative Commons

Health care reform returns, with new data in the mix

For a few weeks, health care reform was the immovable trunk in a political logjam. But new political talks might finally break that jam, just as health care analysts flood it with new data and debate.

The numbers show a counterintuitive trend: insurers are reporting larger profits, even as more and more people go uninsured. The five largest US insurance companies posted a record combined profit of more than $12 billion in 2009, according to a report, despite losing nearly 3 million customers in the down economy. Health insurer Wellpoint topped $2.7 billion in gains; meanwhile, its subsidiary, Anthem Blue Cross, reportedly made plans to raise monthly prices by as much as 39% in California. US Health and Human Services Secretary Kathleen Sebelius described the increase as “difficult to understand,” especially given Wellpoint profits, and she used the incident to catalyze a follow-up report, which showed other drastic insurance hikes.

Continue reading

Speedy sequencers on the move

After researchers last year reported a method for sequencing DNA in real time at the single molecule level, the scientific community has been eagerly awaiting the chance to test out this so-called next-next-generation technology on their own samples.

That wait will soon be over. Pacific Biosciences, of Menlo Park, California, yesterday announced the first 10 recipients of its ‘single molecule real time’ (SMRT) sequencing system. These lucky clients, which were chosen amongst a pool of 30 applicants, should get their kits in the first half of 2010. Similar programs are planned for Europe and Asia later this year, Forbes reports.

PacBio’s DNA sequencers can read continuous stretches of DNA that are thousands of base pairs long at a rate of several nucleotides per second. Such technology could someday allow researchers to sequence an entire genome within minutes for less than $1,000. But for now, each of the awarded institutions will be dishing out close to $700,000 for the privilege of testing out the machines.

Here’s a map of the 10 early adopters:

PacBioMap.jpg

The $200,000 drug club

When it comes to expensive drugs, most people think of prohibitively pricey cancer treatments for which a month’s worth of meds can often cost more than a fancy sports car. But the average cancer patient is usually on such drugs for only a few months, so the annual tab rarely dips into the six digit range.

Drugs for rare genetic diseases, however, require around-the-calendar dosing. And with small target audiences and few if any alternative treatments, many biotech companies are left to charge whatever they want.

Here are the yearly price tags for the nine most expensive drugs, according to Forbes, most of which combat diseases that afflict fewer than 10,000 people around the world. (The number of patients reflects the disease prevalence — not the number of people taking the medication. All figures are for global incidence unless otherwise stated: * Europe and North America; ** US only.)

ExpensiveDrugs.jpg

Click here to enlarge.

The Daily Dose – Wellcome to the future

Wellcome.jpg

— The UK’s Wellcome Trust released its ten-year strategic plan for medical research yesterday. The five challenges it mentions include applying genetics to improve health and investigating the development of chronic disease. Last month, the UK’s Biotechnology and Biological Sciences Research Council outlined its five-year plan, noting among it priorities further basic research into health.

— A survey of almost 250 clinical research projects in the UK found that investigators believe their efforts are hampered by a lengthy drug approval process. The survey suggests that these conditions could lead some scientists to leave the UK in search of more research-friendly environments. (ScienceDaily)

— An anesthesiologist accused of fabricating data for trials of painkillers Vioxx and Celebrex entered a guilty plea yesterday. Scott Reuben, a former chief at Baystate Medical Center in Massachusetts, now faces a different set of hard numbers: repaying over $300,000 in research grants, along with up to ten years in prison. (Pharmalot)

— An investigation into more than 5 million newborn blood samples collected by the Texas government between 2002 and 2009 found that the state gave 800 of the samples to the Armed Forces DNA Identification Laboratory in Washington, DC. The blood samples, which were embroiled in a legal battle over parental consent last December, added to a national mitochondrial DNA database for use in forensics. (Texas Tribune)

Image by Frankie Roberto via Flickr Creative Commons

FBI closes case on anthrax attacks

Bruce_Ivins_award_ceremony_crop.jpg

The US Federal Bureau of Investigation (FBI) last week formally closed the case surrounding the 2001 mailings of anthrax-laced letters to Capitol Hill and journalists in New York and Florida. The bureau concluded that former Army researcher Bruce Ivins was the sole culprit behind the deadly attacks.

Ending its nearly nine-year investigation, the FBI, working together with the US Postal Service and Department of Justice, determined that Ivins mailed the letters, which killed five people and sickened 17 others, because of “intense personal and professional pressure.” He hatched the plan, the investigation concluded, to create a scare that would revitalize an anthrax vaccine project that he had been working on for 20 years. It seems he also carried a deep hatred for New York City, the site of the 11 September 2001 terrorist attacks. Ivins died of an apparent suicide in July 2008.

Continue reading

The rise and rise of anti-retrovirals

Cross posted from Nature’s The Great Beyond blog.

Drugs currently being used to treat AIDS could slow or even stop transmission of the virus itself, two major US conferences were told last week.

Speaking at the AAAS conference in San Diego, Brian Williams of the South African Centre for Epidemiological Modelling and Analysis pushed for anyone infected with HIV – the virus which causes AIDS – to be placed on anti-retroviral drugs. This would severely curtail their infectiousness.

Read the rest of the post on The Great Beyond.