Archive by category | Scientific publishing

Researchers less willing to share study details, according to journal’s survey

Researchers are increasingly reluctant to share the background details of their studies with other scientists according to new results from a survey of authors who published papers in the Annals of Internal Medicine in the last five years. This downward trend in researchers’ willingness to disclose such information is, unfortunately, at odds with the current surge in efforts to facilitate access to the types of study specifics that are vital to reproducing results.  Read more

Immunologist effort aims to improve hyperlinking of research papers to raw data

Immunologist effort aims to improve hyperlinking of research papers to raw data

A study published today in the New England Journal of Medicine reports that people suffering from ANCA-associated vasculitis, a disease in which the body attacks its own defense system, can now be effectively treated with one month of weekly infusions of rituximab, instead of the standard 18-month regimen with daily pills of cyclophosphamide, which has strong side effects. But that is not the only thing that makes the report noteworthy, according to its authors: the study is the first to contain hyperlinked charts or graphs that redirect users to an information-sharing system called TrialShare, where they can instantly access data amassed during this clinical trial and others.  Read more

UPDATED: GSK inquiry reports signs of possible data fabrication in multiple sclerosis paper

An inquiry by the British pharmaceutical company GlaxoSmithKline (GSK) into allegations of possible data fabrication in a 2010 Nature Medicine paper regarding the role of specialized T cells in autoimmune disease has found what it sees as evidence of misconduct. Concerns regarding the paper surfaced last week, when news sources reported that the company had begun investigating the research conducted for the study at a GSK lab in Shanghai.  Read more

Yale immunologist wins new €4 million award

Yale immunologist wins new €4 million award

Most scientists will say that they go to the lab every day out of a pure love of science, not to make buckets of money. But for researchers at the pinnacle of their fields, science can be a lucrative trade. Win a Nobel Prize, and you could take home more than $1.2 million. Bag a Templeton Prize, and you could be depositing a $1.7 million check. Net a Breakthrough Prize in Life Sciences, first awarded earlier this year, and you’d walk away with a cool $3 million.  Read more

Centenarian genetics study retracted

Researchers from Boston University today issued a retraction notice for a controversial paper published last year that purportedly described a predictive test for living to and beyond 100 years. The July 2010 study identified 150 single nucleotide polymorphisms that clustered into three subgroups. On the basis of these genetic factors, the study authors claimed that they could predict an individual’s likelihood of exceedingly long life with 77% accuracy.  Read more

New dimensions in molecular modeling

New dimensions in molecular modeling

This week PLoS Biology, in collaboration with the Structural Genomics Consortium, rolled out “enhanced versions” of two of its articles. Once a browser plug-in is installed, readers see a 3-D molecular model alongside the article. As they progress through the text, the structure spins and zooms in or out to focus on the relevant molecular feature. One of the enhanced PLoS Biology articles details the structure of CaMKIIδ, which senses and transmits calcium signals to aid in cellular signaling. The other is a structural and functional analysis of the human peptidyl-prolyl isomerase family of proteins, which are targeted by the  … Read more

Canadian biomedical research gets central repository

Canadian biomedical research gets central repository

Two years ago, the Canadian Institutes of Health Research (CIHR) mandated that all studies funded by taxpayer-backed grants be made freely accessible within six months of publication. The problem was there was no central repository to store all these papers, so manuscripts tended to be kept on a hodgepodge of publishers’ websites, institutional repositories and elsewhere. Now there’s a solution. As of today, researchers can submit their final peer-reviewed manuscripts to PubMed Central (PMC) Canada, the north-of-the-border spin-off of the US National Institutes of Health’s PMC, a free digital archive of biomedical journal paper.  Read more