NME’s weekly science dose (March 22-28)

NME’s weekly science dose (March 22-28)

This week, it’s genome-sequencing galore, and first up is the falcon.

So, who’s evolving faster: the falcon or the chicken?

In the game of hunter versus hunted, researchers sequencing the genomes of two species of falcon suggest that top predators need to adapt quickly if they are to stay at the top of their game and not risk being ousted from their predatory position.

In the case of the falcons – including the peregrine (the fastest creature on the planet capable of zipping at 320 kilometers per hour) and the saker – their genomes suggest that they are evolving at an accelerated rated when compared to birds such as turkey, chicken and zebra finch.

The finding, contributed to by Jun Wang from Jeddah’s King Abdul Aziz University, supports earlier observations of a rapid rate of new species forming within the falcon lineage.

Another report on a genome sequenced this week features the red seaweed known as the Irish moss. While completely removed from the high speed predatory world of the falcon, this multicellular red algae seems to have quite a unique genome: it only has 9,606 genes, significantly less than even some unicellular algae.

To make sense of such a compact genome, the researchers, including Ahmed Mostafa from the American University in Cairo, hypothesise that more than a billion years ago, red algae experienced a massive loss of genetic material due to extreme environmental conditions. Had this loss not occurred, red algae might have gone on to colonize the terrestrial world – just like green algae, the ancestor of all land plants, did.

A third report highlights the draft sequencing of the genomes of two progenitor wheat species that played important roles in the evolution of modern wheat: Ae. tauschii and the wild einkorn wheat T. urartu.

The Ae. tauschii genome was found to contain a hefty 43,150 protein-coding genes. The data predicted the presence of genes encoding 159 previously unknown microRNAs, some of which may contribute to the ability of bread wheat to grow in low-nutrient soils.

The draft for T. urartu predicted 34,879 protein-coding genes. Its genome also had a slight expansion of the genes associated with disease resistance — containing nearly 600 such genes, compared to 460 in rice and just 106 in maize.

Beyond the hood

Hooked on caffeine? Scientists have just reported on genetically engineered E.Coli bacteria that literally live off of it. The researchers transferred the genetic gear for breaking down caffeine from a natural soil bacterium called Pseudomonas putida – which can actually live solely on caffeine – into E.coli, which is easy to handle and grow.

These can be used to then decaffeinate a drink or even measure the caffeine content of a beverage. Caffeine is already a common water pollutant thanks to its abundance in many drinks and medicines – these bacteria can help decaffeinate our water.

So how would you feel about some decaffeinating E.coli in your next drink?

While you think about that, consider this study just published in the journal Neuron on the nature of decision-making: it suggests that being given time to make a decision does not necessarily lead to making better decisions at all. That, at least, is the case among rats – who according to the study’s author have “surprisingly similar” decision-making processes to humans. Hmm.

In context of this study, when rats were challenged by a series of perceptual decision problems, they fared just as well whether they decided rapidly or took time to respond.

According to the lead author, neuroscientist Zachery Mainen, “There are many kinds of decisions, and for some, having more time appears to be of no help. In these cases, you’d better go with your intuition, and that’s what our subjects did.”

Understanding adaptations may help in animal conservation

© BRAND X

© BRAND X

While falcons have evolved rapidly to become top predators, they are still vulnerable to rapid habitat loss, environmental changes, overexposure to pesticides and overharvesting for falconry.

A study published this week in Nature Genetics looks at the evolutionary history of two falcons: the peregrine falcon – who is the fastest predator in the world, clocked at speeds of 320 Km/h; and the saker, an endangered falcon that is popular in the Middle East and is the national emblem of the United Arab Emirates.

According to the researchers, the two falcons may have diverged 2.1 million years ago. They have rapidly evolved over the years, receiving their distinctive long, wide and curved beaks as well as superior sight to help then in hunting.

However, while the genome of the two falcons offers many clues about their past, there is much to learn there that can help in future conservation efforts and adaptation for these predators. The saker, which is predominantly found in hot weathers and deserts, has evolved genes that help it survive in the arid conditions of its habitats. The falcon has several copies of genes that are responsible for water conservation in the kidneys. Sakers secrete more sodium and chloride in their urine than peregrines, which helps them maintain their osmotic equilibrium.

“The data presented in this study will advance our understanding of the adaptive evolution of raptors as well as aid the conservation of endangered falcon species,” says Shenkai Pan, a bioinformaticist from BGI and one of the lead authors of the study.

Both the peregrines and sakers appear in many places around the world, and their conservation status varies across the globe. Where the peregrines used to be widespread almost all over the world, they became vulnerable in North America due to pesticide use and hunting. Sakers are currently endangered in the Arabian peninsula, mainly due to thousands being hunted every year in the United Arab Emirates, while a strong population still remains in Hungary.

Knowing the genetic basis of the wide diversity these falcons show in habitat can help conservationists put down long-term plans to save the falcons. This look into the past can also help understand the future of these birds of prey, and can help scientists know what they can – and what they can’t – survive.

NME’s weekly science dose (March 15-21)

It’s good to be reminded every now and then that the human species can go extinct pretty much any minute – that’s certainly what happened to half the species on the planet 200 million years ago.

Massive volcanic eruptions were thought to have caused the mass extinction, and now new evidence has pinpointed these eruptions as occurring 201,564,000 years ago – exactly when half the planet’s species abruptly disappeared (at least that’s what the fossil record reflects. They may have all been abducted by aliens for all we know, but… no.)

The study, including Mohammed Et-Touhami from Morocco, lends new evidence to the tight chronology between the eruptions and extinction, further suggesting that the former caused the latter.

Fast forward through the millions of years that Young Earth advocates don’t believed ever happened, and we arrive to our modern world of mammals, cars, and alas, HIV. Being HIV-positive can cause significant cognitive deficits with time, but it now seems these may be reduced by using a steroid hormone called dehydroepiandrosterone – at least among cats.

A team of researchers, including Moroccan researcher Samir Ahboucha (Morocco’s on a roll this week!), found that giving this steroid to “FIV-infected cats” – an animal model of HIV infection – significantly reduced their cognitive and behavioural deficits.

Finally, if we can get away with it, most of us are unlikely to tell our bosses we screwed up if it means we’ll get a nasty mark on our record. It’s an understandable tendency that seems to be stopping healthcare providers in Lebanon from reporting mistakes due to the “culture of blaming rather than learning” that seems to be troubling hospitals there.

A survey of nearly 7000 healthcare providers from over half of Lebanon’s hospitals found that over 80% of them believed mistakes were held against them and recorded in their personal files, making them reluctant to report any mishaps – not a huge problem if you are the hospital’s accountant, but potentially a serious issue if you are a heart surgeon.

Beyond the hood

It’s been annoyingly called the “God particle”, but the “Higgs-like” particle that was discovered at CERN eight months ago is officially now just the “Higgs boson” – it’s already somewhat confirmed existence has been well, re-confirmed.

The positive identification came after researchers were able to examine how the discovered particle decayed into smaller particles – that is, two Z bosons, which in turn break down into two muons each – exactly as the Standard Model predicts.

 

That’s it for this week but stay tuned to next week’s roundup of what’s happening in the world of science in the Middle East and beyond!

Qatar surpasses US in obesity

Ravinder Mamtani

Ravinder Mamtani
WCMC-Q

The obesity epidemic in Qatar may have just overtaken the United States, which was long the world leader. According to new data release by the Supreme Council of Health, about 70% of people in Qatar are overweight and some 41% are obese.

“These diseases, as science has shown, kill prematurely, they compromise quality of life and we also know they are influenced by behavior,” said Ravinder Mamtani, associate dean for global and public health at Weill Cornell Medical College in Qatar (WCMC-Q).

Rapid urbanization in Qatar, and many other states in the Arab Peninsula, following the discover of oil has contributed to a sedentary lifestyle. Coupled with a lack of exercise culture and diets high in fats, salts and sugar, obesity has rapidly increased in the Middle East.

The new data was presented in a symposium organized by WCMC-Q and co-sponsored by the Supreme Council of Health. The rapid increase in obesity has led to an increase in several non-communicable diseases in the small Gulf country, such as diabetes, cardiovascular diseases and some cancers. According to the International Diabetes Federation (IDF), the rate of diabetes in Qatar has climbed to 20.2% of the population.

“Often we think that we need to do a lot to prevent these illnesses. That is not the case. Often simply making some marginal changes will help,” said Mamtani. The incidence of these diseases can be significantly reduced by simple lifestyle changes, such as increased regular exercise and opting for a healthy diet, he adds.

The symposium also saw the launch of the new Journal of Local and Global Health Perspectives from QScience.com. The journal is open access and peer-reviewed, providing a global perspective on health issues and public health strategies.

NME’s weekly science dose (March 7 to 14)

Hello reader! Welcome to our new, weekly roundup of what’s happening in the science world. Each week, we will wrap up the latest in science from the region and present it  in one, easily digestible dose. We will also highlight two or three findings from the broader science world that we think are particularly interesting. Enjoy.

Did you know that just 1% of researchers in Saudi Arabia were women in 2011? Geneticist Lihadh Al-Gazali lays into the social barriers shackling women scientists in the Arab world this week, part of our coverage highlighting International Women’s Day.

Egyptian biomedical scientist Nagwa El-Badri also takes a swing at the “arrested potential” of Egyptian women in science — though 60% of entry level faculty positions are held by women, only 20% become professors.

In Lebanon, however, one insidious factor that is affecting all genders is in the very air they are breathing. Our Beirut-based correspondent Andrew Bossone reports here on the public health risk arising from the use of diesel generators in compensation for the country’s chronic energy problem.

But it’s not all bad news: a new strain of the coronavirus (which normally causes only mild respiratory illness) appears to have killed off 7 of the 13 individuals it’s so far infect. No wait, that’s more bad news.

The good news is, researchers — including virologist Ali Zaki from Saudi Arabia — have identified the protein allowing the virus entry into human cells, potentially paving the way to an effective therapy to stop infection.

Beyond the hood (i.e. Middle East)

It’s something that keep us folks at Nature Middle East up all night at times: what if it was our cousins the Neanderthals that had become the supreme homos (of the genus Homo, that is)? What if it was us who had gone extinct instead?

A new study of our relatives’ skulls suggests they may actually have gone extinct because they had larger eyes than ours. Too much of their brains were caught up processing visual stimuli it seems, while our brains had more resources available to endow us with the higher level cognitive processes that eventually led us to invent things like — Facebook?

Speaking of which, it appears each time we hit that Like button on FB, we are giving away all kinds of info about our personal attributes: from sexual orientation, to drug use and religious affiliation.

A new study found that by analysing our Likes, researchers can predict one’s religion with 82% accuracy, political party membership (in the US, 85% accuracy), and even whether we smoke cigarettes (73% accuracy).

The researchers also found that individuals who like Nature Middle East links are highly intelligent and inherently awesome. (Yes, we made that part up, but we all know it’s true).

Students launch popular science magazine

The VectorThe Arab world has a serious problem when it comes to science communication. To put it frankly, there’s hardly any of it – and what little there is is of such bad quality that the public is not interested in even coming close to it (that is if they even heard of it).

While science journalism is booming here (even though it is shrinking in many places in the West), public engagement to raise awareness of science and innovation remains minimal. There are a few really good initiatives to engage the public with science, such as FameLab or Stars of Science – but they are few and far between.

But some young students from the German University in Cairo (GUC) who are passionate about science decided to take their fascination a step further and launch the first student popular science magazine in Egypt. This could even be the first such student effort in the Arab world.

The magazine, which they are calling The Vector, will start by covering research on and off the GUC campus in a format accessible to anyone interested in science. It will also cover research happening internationally, with articles that span both physical and biological sciences.

“With a heritage of poor science curricula in terms of content, approach and presentation  simply speaking the world ‘science’ is sufficient to invoke a string of dull memories to the average Egyptian,” says Youssef George, the editor-in-chief of the new magazine. To counter this, he suggests the written word will not be enough. “In a community in which most individuals gather information from audio-visuals, it is inevitable to go for that at a later phase.”

The magazine will start as an online publication, launching its first issue next May. However, the students hope to have a monthly print edition by September 2013.

The magazine will stay a student project, so when the current students graduate they will be replaced by new students, always keeping fresh blood flowing. “The transient nature of university life makes it impossible for any one person to stay in their position for too long,” says Sara Khaled, the magazine’s managing editor. “The dynamic nature of the team would always ensure that the quality of the production is based on a coordinated team effort, rather than the individuals running it.”

High on the agenda of the launch team is to build a solid foundation that others can build on and grow in the future, once they have graduated and left university. They will not completely leave the project behind, however, but will continue offering advice and support to the subsequent teams taking the magazine forward, explains co-news editor at The Vector Reham Tarek, always keeping them motivated and passionate about what they are doing.

To start if off, the students are relying on freelance volunteers to supply the stories and articles. A long recruitment process on campus has yielded many interested people who were excited to take part in the effort – even several not majoring in sciences. “We want to give them the opportunity to learn and grow as part of The Vector team. This is the core part of our vision.”

It is this vision, which every member of the team completely believes in, that is driving force for the project. Their belief that they must help “gradually refine science-centred thinking, both locally and regionally, and to continuously help nurture it with the best of science news from all over the world,” as Alaa Madi, the chief biological sciences editor puts it.

“What keeps us motivated is that we are starting out at a time where there are many science communication initiatives that have paved the way, such as Nature Middle EastSciDev.Net and FameLab, that have collectively created a scientific awakening and encouraged us to continue from there,” adds George.

Why FameLab matters

The winners of the first FameLab Egypr 2013 heat in Cairo University.

The winners of the first FameLab Egypt 2013 heat in Cairo University.

I have often visited the prestigious Cairo University grand hall to attend lectures or talks by prominent researchers and politicians – including Barack Obama on his first trip to an Arab state after he became the US president. Early this week, I found myself sitting there in the front rows again, but instead of world-renowned figures, it was dozens of young undergraduates and postgraduates taking the stage for the first leg of the FameLab Egypt competition.

For those unfamiliar with the competition’s concept, it involves groups of young people passionate about science going on stage to explain a scientific concept of phenomenon in three minutes. They cannot use any powerpoint presentations or charts – just small props they can bring on stage. The trick is they must do this in an exciting, engaging way that is easy for a non-scientific audience to understand.

Over 45 young people competed, talking about topics ranging from the potential of biofuels to how neurotransmitters work and everything in between. Some were captivating, sending the audience into a frenzy of applause while others were less so, but not a bit less impressive. And that is why FameLab really matters.

The competition is one of the best science outreach efforts in Egypt – and probably in the Arab world. The audience was full of young people eager to listen to science. Additionally, many of the contestants had never been on stage before, let alone explained a complex scientific theory in a simple, approachable manner. They were building up and acquiring new skills that will, in the future, make them excellent science communicators – should they choose to pursue that career.

We have repeatedly argued here that we need more outreach efforts to generate interest in science among the public. By having the young people present science in this fun and simple manner, they manage to engage the audience much more effectively that the writings of many science journalists in Arabic news media outlets. They are effectively breaking down this barrier that the layperson has in their mind towards science.

A top notch panel of judges, ranging from a movie superstar to journalists and scientists, comments on each performance, judging the contestants on content, clarity and charisma – offering them advice on how they can improve their presentation and outreach skills. These are tips from professionals that the contestants might not normally have access to. This further hones the young people’s skills as science communicators.

At the end of the day, it is not about winning or losing. After all the heats and the finale conclude, only one contestant will represent Egypt in the international leg of the competition during the Cheltenham Science Festival in the UK. However, I hope that the competition can have a ripple effect far outside the grand hall in Cairo University.

I hope we can see more young and old people from those who were in the audience hungry to learn more about science. I hope that some of the amazing contestants who didn’t make it will have had a taste of how wonderful it is to communicate science and go back and work on their skills and join the competition again next year. I hope the winners of the heats manage to find sponsors who would be interested in science communication and continue on this career. I also hope the winner who represents Egypt in the UK wins the international award!

But ultimately, and above all, I hope that people realize how positive this initiative is in the dearth of science communication that spreads across the Arabic-speaking Middle East.

Unfortunately, the only Arab country taking part in FameLab this year is Egypt. This is indeed a pity, considering there are exceptional people across the whole region waiting to be discovered, and that not a single state in the region does not need more science outreach.

The snip: Is male circumcision justified?

An ancient Egyptian fresco depicting a circumcision ceremony. Source: Wikipedia

An ancient Egyptian fresco depicting a circumcision ceremony. Source: Wikipedia

Circumcised men experience significantly lower levels of sexual pleasure and orgasm intensity compared to those uncircumcised, according to a recent study from Belgium.

For us gents in the Middle East and for male Muslims all around the world, who make up nearly 70% of the world’s estimated 1.3 billion circumcised men, the question naturally arises: Just what have we been missing out on?

According to the study, based on a survey of 1,369 men responding to leaflets handed out at railway stations across Belgium, we are missing out on anywhere between 0.2 and 0.4 points in reduced sensitivity and sexual pleasure when the penis’s head — the glans — is stimulated during arousal.

But what do these numbers translate to in the bedroom?

The survey asked participants whether they were circumcised and had them rate how sensitive their penis was on a scale from 0 to 5, with higher numbers corresponding to higher sensitivity.

For instance, the researchers report that in regards to sexual pleasure on the “dorsal side of the glans”, those uncircumcised averaged 3.72, while circumcised men were at 3.31.

Orgasm intensity was similarly reported as higher among the uncircumcised men, who averaged 3.37 compared to 3.13 for those circumcised — hence the 0.2 to 0.4 point difference noted above.

The findings contrast with a 2007 study published in the Journal of Sexual Medicine that found no loss in sexual sensation among circumcised men.

Some scientists have criticized this latest study, published in the peer-reviewed journal BJU International, as lacking proper scientific and editorial review.

For instance, the researchers’ depiction of their results in Table 3 of their paper conveys the exact opposite of their conclusions, showing circumcised men to have greater sensitivity and orgasm intensity.

While this is likely a mere editorial mishap, the study also features other curiosities.

For example, among its findings is that “circumcised men indicated lower orgasm intensity at the dorsal and lateral sides of the glans.”

Such a conclusion was derived from answers to questions asking participants to assess the degree of orgasm intensity from the stimulation of the lateral shaft of the penis, and alternatively the dorsal and ventral sides.

As the owner of a penis, I have absolutely no idea how one might begin to answer such questions.

Pinpointing orgasm intensity to particular dimensions of the penis sounds like asking a victim of an explosion whether they felt the thrust of the bomb impact more on the side of their body or its front. It seems a borderline comical question.

Moreover, the researchers indicate that 23% of the respondents were circumcised, meaning the sample was not representative, as circumcision rates in Europe are generally much lower. This raises more questions about the motivations of the circumcised individuals who decided to respond to the researcher’s leaflets, calling into question the reliability of their self-assessments.

But why snip at all?

Ultimately, even if these findings are inaccurate, this would be irrelevant to the justification of a — on the face of it — quite bizarre practice. Indeed, it is tempting to wonder what depraved, if not altogether insane, parent first decided it might be a good idea to rip off a part of their son’s penis.

In the context of the Middle East, Judaism, the Coptic church and Islam all prescribe circumcision. In the latter faith, the practice is known as tutheer, or purification, and while not mentioned in the Koran, circumcision is considered essential to lawfully make the pilgrimage to Mecca.

But is there something to be said for circumcision beyond the dictates of dogma?

Historically, the first recorded circumcisions date back to 2300 BC, when ancient Egyptians removed the foreskin — according to one theory — in order to avoid infections of the glans resulting from sand under the foreskin.

Others suggest that circumcision predates human history, with the practice potentially arising even prior to the migration of Homo sapiens out of Africa. Based on this, one study argues that if it had no survival advantage, it would be unlikely for the practice to persist so long.

In the modern age, the most consistently reported advantage of circumcision is its potential role in combating HIV.

“The evidence showing a major, statistically significant protective effect of male circumcision against HIV infection is irrefutable,” says Roger Short, a reproductive biologist and HIV prevention expert at the University of Melbourne, Australia.

“[This is] the reason why the World Health Organisation  is promoting male circumcision throughout Africa in its efforts to reduce the incidence of HIV infection,” he says.

Short explains that it appears to be the inner aspect of the foreskin that is richly supplied with HIV receptors, making it the main site of HIV entry into the penis. Hence, removal of the foreskin may reduce the risk of HIV by 60 percent.

Other evidence suggests that circumcision can also cut the risk of herpes by 28 percent and penile cancer causing genital warts by up to 35 percent.

Whether this justifies perceiving circumcision as a kind of weak vaccine against these conditions is a debate that’s slowly garnering more attention — particularly after a German court banned circumcision last year on the grounds that it constitutes bodily harm to children.

Ultimately, while a simple resolution may be to argue for keeping this a matter of parental discretion, just what rights parents should have over their children’s bodies is likely a subject with even greyer ethical boundaries.