Blood on the lab bench

Scientists in Qatar have taken research into organ development one more step into the future by expanding the potential for creating personalized blood and heart tissue in the lab.

The scientists, under the lead of Arash Rafii Tabrizi at Weill Cornell Medicine – Qatar, have postulated that endothelial cells, which line the walls of blood vessels, are a vehicle for organ development. “Different organs have different endothelial cells that express different and specific factors called angiocrine factors that lead to the development and function of the organ,” explains Tabrizi.

In order to test this, the scientists forced the expression of said transcription vectors in the lab. Twenty days later, the cells multiplied and differentiated into the building blocks of blood cells: hematopietic stem cells. These are the basis for cells such as red and white blood cells and platelets.

“If you have leukemia, for example, we would retrieve your endothelial cells and we could transform that into blood. It would be an unlimited personal source of blood for each individual,” says Tabrizi.

In addition to blood, the researchers paired endothelial cells with heart muscle cells to create more muscle cells, that beat together rhythmically, in a petri dish.

The scientists maintain, however, that it’s too early to make any sweeping assumptions about the reliability of results, not until the tests move into the animal and human trial phases.

Read more about what the scientists have termed a breakthrough discovery here.

 

2014 Year in Review: Nature Middle East highlights

In retrospect, 2014 was a mixed bag for the region – with some significant research produced on one hand, but on the other, in some countries, education, health and sectors in academia received some hard blows as a result of conflict and war.

In Syria for instance, the risk of infectious diseases is at its highest, warned a study published in PLOS Pathogens. The crisis was branded “a public health emergency of global concern” – with vaccine-preventable diseases not only reappearing in Syria but spreading to other countries with the outpouring of refugees, such as Lebanon and Iraq, which itself is reeling from years of damage to infrastructure and a myriad of health disasters.

Outbreaks of polio were reported – years after the Middle East was deemed “clean” – with WHO, UNICEF and ministries of health rushing to contain it. But even the largest vaccination campaign in the region’s history couldn’t reach its target as hundreds of thousands of children remain vaccinated, especially with access to hot zones barred.

Measles and rubella continue to be a burden in Syria, and in one instance, the vaccine killed instead of saved. At least 15 children died last September after being administered vaccines that were wrongly formulated, probably turning families away from seeking it and leaving many children unprotected.

Also in Syria, the lack of medical personnel is forcing untrained volunteers to tend to the injured and sick in hospitals.

Adding insult to injury, a study in The Lancet this year says that civilians aren’t even a priority for hospitals in a country like Syria, torn by civil wars. Fighters take up the majority of the available spots. In other hospitals, doctors risk their lives when they treat patients from the “opposite camps.”

In Iraq, the Islamic State (IS) is spreading its own brand of terror – taking over big universities and closing them down, including the historic University of Mosul. The education hubs are now used as makeshift camps for the militants. An independent Baghdad-based research tells Nature Middle East that soon conducting quality research in Iraq will be impossible. Skilled professors are already migrating in droves, in fear for their lives. “Many won’t come back even if the conflict ends,” says the researcher.

The International Center for Agricultural Research in the Dry Areas (ICARDA) conservation agriculture project that helps local farmers increase food production has been in jeopardy in Iraq since IS takeover. Insecurity, fuel shortages and lack of necessary equipment is breaking them, they decry.

Nearby, an estimated 3,900 schools in Syria had been destroyed or closed down during the first two years of the war. By April 2013, “22% of the country’s 22,000 schools [were] rendered unusable,” according to UNICEF.

The year 2014 also saw a comeback by Middle East respiratory syndrome coronavirus (MERS-CoV), which killed and inflected hundreds worldwide across 19 countries, with most of the infections concentrated in Saudi Arabia, where the virus was first discovered.

Nature Middle East was lucky to exclusively speak to the Egyptian virologist who first identified the virus, telling us the story of “patient zero” who died from an acute respiratory condition which was later revealed to be MERS itself. The mystery of MERS’ transmission was not lifted in 2014, but at least some countries are speeding up research into antiviral drugs that could contain it, or hinder its spread. Still, the fact remains, there are no anti-MERS drugs on the market so far.

In fact, overall things have been going south – health wise – for many in the region; not counting conflict victims and health complications due to war. A silent yet lethal predator, diabetes, has been preying upon the masses – with 35 million diagnosed with type 2 diabetes in the region.

Essentially, we have the  highest prevalence level of  in the world – with 1 in every 10 people living with it. Type 2 is tied to lifestyle, while type 1 has to do with genetics, autoimmune and environmental factors – and the incidence of the latter is rising sharply.

The highest rate of type 1 diabetes is in Saudi Arabia, with a shocking incidence of 14,900 children living with the disease, approximately a quarter of those in the Middle East and North Africa.

But in slightly better news, the region has managed (so far) to evade Ebola, which transmits through direct contact with bodily fluids and gains access to the body through skin abrasions and mucous membranes. The virus, however, has culled many in the central parts of Africa, and has fatality rates of up to 90%.

In terms of research, the region has been more prolific. Nature Middle East‘s chief editor Mohammed Yahia writes about the freshly released Nature Index, which was released in November and tracks where high impact research is being conducted around the world, and it shows many positive trends in the region – with Saudi Arabia leading with 358 papers, followed by Egypt.

Examples of prominent regional research includes one showing how Neolithic North Africans began exploiting cereal crops at least 500 years earlier than previously thought, published in PLOS ONE. The earliest evidence of cereal crop domestication in North Africa comes from the Fayum area of middle Egypt, and dates back to around 4350 BC.

In Lebanon, researchers from the American University of Beirut identified an algae species that can be a possible source of superfood and cheap renewable energy. In neighboring Syria, it turns out, two areas have the world’s highest concentration of wild-growing crops. The potential for these crops, distantly related to today’s agriculturally produced crops, lies in their gene pool, and adaptability – something that can provide breeders with genes that could enhance crop resistance to stresses such as climate change, pests, and disease.

Other breakthroughs include: In Sudan, a stunning discovery of a 3,000-year-old skeleton with metastatic carcinoma challenges the notion that cancer is a modern disease, opening new horizons for specialists to research cancer’s etiology and evolution. The ancient Nubian is probably the first cancer victim in archaeological record. As well, dinosaurs lived in Saudi Arabia, it seems. Fossilized remains identify specific dinosaur species from millions of years ago in the Arabian Peninsula when the area was covered by lush vegetation.

That being said, this year was not easy on the region, and infrastructures that provide the backbone of scientific endeavors have bore the brunt of political upheavals. In terms of progress – if we choose to compare notes with developed countries – we’re only barely inching forward.

Independent or university-backed research in the Arab world, collaborations with world-class institutions notwithstanding, is not enough to help Arab-affiliated researchers catch up with an incredibly prolific West. Governments must step in, opines Nobel laureate Ahmed Zewail and the academic president of Zewail City of Science and Technology Sherif Sedky.

“Renaissance in the Arab world will not be possible without genuine government recognition of the critical role of science in development and policies providing commensurate funding for basic research and reform of rigid bureaucracy which thwarts progress,” the experts say.

And considering it’s politics that seems to be setting the region back, Zewail and Sedky’s words ring true.

It is essentially a tug of war – between competent scientists and experts who’re aspiring to propel this region into the future, and governments staggering to make ends meet for their people, giving science a cold shoulder in the process. The next year may not tell us who wins, but it may very well give us indications – through statistics above all – of who is tugging harder.

Qatar’s peculiar research funding dilemma

Qatar Foundation

{credit}Qatar Foundation{/credit}

While most countries around the world are dealing with shrinking budgets for science research, Qatar has a surplus that the small Gulf state doesn’t know what to do with.

A few years ago, Qatar pledged 2.8% of its annual GDP to science and research – more than any other Arab state. However, according to Faisal Alsuwaidi, president of Research and Development at Qatar Foundation, the country isn’t currently spending even 10% of that amount annually.

“Our current spending is a fraction of what is available. The reason is that we are still recruiting, we do not have enough manpower yet,” he says. “The latest statistics show that Qatar has about 600 scientists, we need to add 1500 more by the year 2018 to meet our research targets.”

While Alsuwaidi declined to give an exact number for the amount of money that Qatar is currently spending on science, he said it is substantial when compared to other states similar to Qatar in size and population. The budget pledged for science research will continue to increase year by year by 15-20% until they hit the 2.8% of GDP target, and he stressed there are no plans to decrease funding. “This would cut into our plans and that is the last thing Her Highness [Sheikha Moza bint Nasser] wants to see.”

While money is not holding back research and innovation in the rich Gulf state, Alsuwaidi acknowledges the real challenge Qatar Foundation is facing is changing the general culture. “In the Arab world we do not have a science culture. I come from industry and when I had an issue with my plant I contacted engineers or manufacturers, I didn’t call in scientists. We want to change that.”

Thomas Zacharia, executive vice president of Research and Development at Qatar Foundation, says this is the long-term plan that they are working on. “The research we are trying to build is a central part of how the country is moving forward. We have to do many things systemically, we are not going to get [a science culture] in one day. You have to do various things to make this successful.”

During this year’s Annual Research Conference in Qatar, Qatar Foundation announced its new research strategy – which focuses on three grand challenges they want to tackle through science by 2020: energy, water and cyber security.

“We thought there was a disconnect between the ambition of diversifying the economy of the country with the scope and scale of the research so what we did is focus the research in a particular way in order to achieve the goals of the country,” says Zacharia.

“I am very pleased with the outcome of this year’s strategy,” adds Alsuwaidi. “In theory it encompasses a number of objectives from last year and we are trying to hire experts of international renown. We are attracting international attention and we are making ourselves known internationally.”

Desert farming pilot yields positive results

Sahara Forest Project

{credit}Sahara Forest Project{/credit}

After two and a half years of research and testing, the Sahara Forest Project pilot in Qatar has started to yield results, and initial findings are showing good results for arid land agriculture.

The pilot project, built on one hectare of land, produced 75 kg/m2 in three crops annually, which is competitive with those obtained in commercial farms in Europe. The project, however, uses seawater instead of freshwater. The greenhouse, where the plants are grown, uses seawater and blowing winds to create a cooling effect which allows the plants to grow even under the scorching summer heats of Qatar, explains a news story in Science. Pipes with cold seawater passing in them causes some air moisture to condense, which is the source of freshwater plants use.

The cold moisture coming out of the greenhouse also allowed plants to grow outside the greenhouse, and the operators were able to use “evaporative hedges” which brought temperature down by a further 10°C, which allowed desert plants to grow quicker than normal and throughout the whole year. The final component of the pilot is a concentrated solar power plant which provides energy to run the project and any surplus is used in desalination of saltwater for extra freshwater. The salt end product was collected in large pools, and researchers are trying to grow salt-tolerant algae that can be used as animal fodder or grown for bioenergy production in the pools formed.

“The remarkable results demonstrated on the ground reveal the potential for enabling restorative growth and value creation in arid land,” Joakim Hauge, CEO of the Sahara Forest Project, told reporters. According to Hauge, scaling the project to 60 hectares can cover all of Qatar’s current  imports of  cucumbers, tomatoes, peppers, and egglants. The question is, however, is this commercially feasible? The reports don’t explain how much producing these food crops would cost.

The Sahara Forest Project will launch a new, 20 hectares pilot near Aqaba in Jordan to test the commercial feasibility of the project.