Educating Excimer: The End of the ‘Cookbook’ Lab

[Joining The Sceptical Chymist is our latest guest blogger, Aaron Finke. A grad student at the University of Illinois, Urbana-Champaign, he works on polyphenylene dendrimers and hyperbranched polymers. You may know Aaron better as Excimer from his posts at Carbon-Based Curiosities.]

I will be focusing most of my energies on these guest-blogging posts to chemical education. This past semester, I had the opportunity to be in charge of a large laboratory course — specifically, the organic chemistry lab course for non-chemistry majors. The “behind-the-scenes” experience I got was an eye-opening one in many ways, from a pedagogical, professional, and personal perspective. I will attempt to recount my experiences and lessons learned here.

A large portion of the students in my lab course were pre-medical and pre-veterinary students, and took it to satisfy the requirements for getting into their respective programs. A majority of the students took this course with the full recognition that it was merely a hurdle for them — a hoop to jump through with no relevance to the future careers to which they are aspiring.

I can’t blame them for having that mentality. The course is an organic chemistry laboratory course, designed to introduce procedures and methods in the synthesis and purification of organic molecules… skills that are mostly irrelevant to those outside of organic chemistry. They learn and perform techniques like extraction, column chromatography, recrystallization, basic organic synthesis, and so on. I use a majority of these techniques every day. But I am an organic chemist. The 500 students in my class are not. It is highly unlikely they will actually use the specific skills implemented in the course, unless they plan on distilling their own whiskey! [Editor’s note: This is illegal in many countries]

The skills students SHOULD be learning in laboratory classes are more general, and, with a “cookbook” chemistry curriculum, are not developed in any capacity. A report which came out June 4, co-authored by the Association of American Medical Colleges (AAMC) and the Howard Hughes Medical Institute (HHMI) and entitled “Scientific Foundations for Future Physicians”, outlines eight core competencies that pre-medical students should demonstrate before entering medical school.

The second competency listed concerns lab courses: “[The student should] demonstrate understanding of the process of scientific inquiry, and explain how scientific knowledge is discovered and validated.” Interestingly, the guidelines indicate only three chemistry-specific goals: gathering primary data for mixtures of compounds, using stoichiometric analysis to determine yield, and, most interestingly, demonstrate a knowledge of instrumentation such as NMR, mass spec, X-ray, etc. These goals, ideally, should be implemented with a focus on discovery, making conclusions, and understanding error.

Most pre-med organic chemistry lab experiments focus on only one of those three things — characterization without application; or synthesis without full characterization — and I dare say few, if any, display a heavy focus on instrumentation. This report acknowledges that advances in medical science and medicinal chemistry rely heavily on modern instrumentation, and yet outdated chemical identification methods are more heavily emphasized in most basic lab courses. When was the last time anyone had to make a semicarbazone derivative of a ketone outside of a lab course? These are secondary or tertiary methods of identification to modern organic chemists. It is enough to know that they exist. But if medical students are to understand the modern literature, they should be taught modern chemical methods. And in their o-chem labs, they are not.

In my next post, I’ll discuss what some chemistry educators are doing to fix the problem of relevancy in lab courses.

[Posted on behalf of Aaron Finke]

Reactions – Carolyn Bertozzi

Carolyn Bertozzi is in the Department of Chemistry at the University of California, Berkeley, and works on the development of chemical tools for probing biomolecules in living systems, as well as specific projects in the areas of glycobiology, mycobacterial metabolism, and nanotechnology.

1. What made you want to be a chemist?

I started out majoring in biology in college, which included the obligatory year of organic chemistry. I fell in love with the subject during that year, thanks in large part to excellent professors, and then switched my major to chemistry – one of my life’s best decisions.

2. If you weren’t a chemist and could do any other job, what would it be – and why?

If I had the talent then it is a no-brainer: professional rock musician, preferably electric bass (I bought one in a mid-life crisis moment but I still don’t know how to play it). Otherwise, I would work on the staff of a professional sports team, either as an analyst or scout. Football ideally, but baseball would be fine too.

3. What are you working on now, and where do you hope it will lead?

We are heavily invested in strategies for imaging glycans in living systems. We worked this out in models of zebrafish development and would like to push the techniques into diagnostic imaging for human disease. We also developed an approach to proteomic analysis of glycosylation that has the potential to reveal disease biomarkers from highly complex bodily fluids. On the nanoscience front, we are working hard on a method for imaging tissues at the nanometer scale using mass spectrometry methods. And a whole lot more…

4. Which historical figure would you most like to have dinner with – and why?

My paternal grandmother – she is not “historical” in the global sense, but she is to me because I did not know her well but she was a legend in our household. She passed on when I was in elementary school and did not speak English well enough for me to communicate with her when I was a kid. Her brief story is this: Grandma fled from Italy to the US during Mussolini’s fascist regime of the 1920s. She was very active in the Italian socialist party and helped build one of the first day care centers in the country to facilitate women’s entry into the work force. Her political alliance put her life at risk, however, so at the age of 19 she posed as an illiterate peasant and escaped on a boat to the US. After landing in Boston, she met her husband, had five children during the depression era (there is a liquor bootlegging story embedded in there somewhere), sent them all to college and post-graduate degree programs on full scholarship (including the girls), and lived to see her youngest, my father, become a professor of physics at MIT. What an experience it would be now to hear her tell her story in person over a big Italian meal.

5. When was the last time you did an experiment in the lab – and what was it?

Circa 1996, I scaled up starting materials for my graduate students. A few distracted attempts at experimental work thereafter earned such criticism from my students that I have deferred to them ever since.

6. If exiled on a desert island, what one book and one music album would you take with you?

The music album: Beatles Revolver

The book: if exiled for a limited time, then War and Peace – otherwise I will never ever finish that tome. If exiled indefinitely, then something X rated would be warranted.

7. Which chemist would you like to see interviewed on Reactions – and why?

My colleague Richmond Sarpong, to see if he will admit in a public forum his secret career aspiration of dancing with the stars