DD11: Stanford and Scripps

So, the conference is over, but the work of a Nature Chemistry editor isn’t. As you might have heard on the podcast, we’re combining our conference visits with trips to nearby chemistry departments. So the day after we’d wrapped up DD11, I took the (surprisingly far) journey to Palo Alto on the other side of the San Francisco bay to visit the chemistry department at Stanford University.

This is my first set of lab visits, and my main impression so far is that it’s like having a day of one-to-one tutorials with some of the best chemists in the world! I wonder how much you’d have to pay to get that kind of consultancy…?

Another impression is ‘interdisciplinary’: it’s impossible (and essentially worthless) to pigeonhole any of the faculty I met into the traditional disciplines of chemistry. For instance, Chris Chang at Berkeley makes organic molecules so they can interact with inorganic species in the body and then give some sort of physical response!

And so on to the Scripps Research Institute in La Jolla (nr San Diego). There’s a strong emphasis here on organic chemistry/biochemistry because Scripps is a biomedical research organisation. Again, more interdisciplinary work…apart from Phil Baran, who proudly does undiluted organic chemistry. He has a quote on his wall (and on his homepage) from his Scripps/ETH colleague Albert Eschenmoser, the key part of which is “neither biology nor chemistry would be served best by a development in which all organic chemists would simply become biological”. I’d like to think there’s space, and funding, for both approaches.

And finally…the Berkeley summer visitor housing I was staying in is right next to the university’s Hearst Greek Theatre, and on my last night there, I was treated to a free concert by Alison Krauss and Robert Plant (formerly of Led Zeppelin).

From La Jolla, Neil

Neil Withers (Associate Editor, Nature Chemistry)

NChem Research Highlights: total synthesis, multimetallic complexes, and photoresponsive elastomers

It’s time for another batch of research highlights.

First up, fresh back from his trip to Korea, Steve writes about a counterintuitive approach to creating stereocentres: by destroying them first!

Second, the story of greedy metal complexes. Neil tackles the synthesis of a series of heteromultimetallic complexes that contain up to 7 (that’s SEVEN!!) different metal atoms.

Lastly, I get to grips with a motor driven by a light-sensitive elastomeric belt.

Finally, news that wine-lovers across the world can be happy about (I’m off to Napa, California, in a couple of weeks so I’m happy). Eating meat is healthier with a glass of wine than without (maybe it’s not that simple but that’s how I’m going to understand it!). The original paper can be found here.

Gav

Gavin Armstrong (Associate Editor, Nature Chemistry)

Reactions – Aline Miller

1. What made you want to be a chemist?

As a child I remember being given a chemistry set and spending many hours in the family greenhouse mixing different coloured liquids and causing things to heat and sometimes burn (much to the horror of my parents!). This fascination of exothermic reactions continued throughout school and then it was a hard decision between chemistry and physics. I ended up choosing chemistry as there were more girls on that course at the time.

2. If you weren’t a chemist and could do any other job, what would it be – and why?

I would definitely like to be a travel writer as I love to visit new places and experience different cultures, so to get paid to do this would be fantastic. However, if I am thinking about my carbon footprint, and about seeing my family, then I would most probably open up a tea shop, so I could sell the cakes that I love to bake (and eat).

3. How can chemists best contribute to the world at large?

In addition to the current push to reduce pollution and improve the environment, I think chemists play a key role in improving health, quality of life and every day well being. I see this as not only making more effective medicinal treatments that are available to all, but also small things like improved material properties and personal care products.

4. Which historical figure would you most like to have dinner with – and why?

Well, the obvious one would be Dorothy Hodgkin as I think she managed to make such a contribution to science, inspire her students and raise her family at the same time and I would like to ask her how she did it! Although if I just had to choose one then it would be Leonardo da Vinci as he was such a great thinker and a pioneer in so many areas including science, anatomy and engineering. I think it would be so fascinating to find out what influenced and inspired him. I believe he was also the first to really take inspiration from nature to create highly functional materials & systems, which is something highly relevant to my research area today!

5. When was the last time you did an experiment in the lab – and what was it?

Ermm? I am ashamed to say that it was a while ago! I did some cryo-transmission electron microscopy with our collaborators in Helsinki, Finland about two years ago on a protein hydrogel. My student was with me though (and she also showed me what to do!) so I am not sure that counts. On the other hand I made some dough for a pizza last night, so you could say my last experiment was fermentation.

6. If exiled on a desert island, what one book and one CD would you take with you?

Unfortunately I don’t a great deal of spare time for reading at the moment between work & having two young children who believe they should only sleep when it gets dark (great for winter, not so good for long summer nights!)! If I had to choose one however, it would be the last Harry Potter book by J.K. Rowling. Choosing one CD is hard as I have quite eclectic tastes, but I should be true to my roots and choose the Scottish band Deacon Blue as they would instill passion for me to find a way back home!

Aline Miller is in the Manchester Interdisciplinary Biocentre at the University of Manchester, UK, and works on understanding how nature uses self-assembly to create functional nanomaterials and attempts to mimic and exploit this in synthetic systems.

Amazing green moving light thingy. It’s chemistry!

This is one of the best chemistry videos, nay one of the best videos, full stop, I’ve ever seen.

The video accompanies a paper (abstract here, subscription needed for full paper) in Organic Letters about a photochromic molecule (one that can change between different forms when hit by light of some kind) that flips back and forth really quickly when UV light is shone on it.

The molecule changes from colourless to green, and that’s pretty much the best thing about it – so look at the video.

If you want to know more about the chemistry, which you might, then I can tell you that the molecules are hexaaryldiimidazole derivatives, and are a cyclic systems containing naphthalene units.

These kind of materials are used in spectacle lenses that change colour in bright lights. But really, just watch the video, that’s all you need to know.

[Hat tip: The Chem Blog]

ChemPod 6

The new chemistry podcast from Nature is now online and can be found here.

In this special nanotechnology show, we discover how a team from MIT are getting nanoparticles into cells, do a spot of interstellar chemistry with an escaping sugar molecule, issue a health warning for those working with carbon nanotubes, and we take a look at the latest online tool helping chemists get hold of chemical information – for free.

Oh yeah… I nearly forgot… Neil and I make our podcasting debuts, calling into the studio to chat about the travel plans of the Nature Chemistry team now that conference season is upon us.

Enjoy!

Gav

Gavin Armstrong (Associate Editor, Nature Chemistry)

DD11: Main group rennaisance

Greetings from Berkeley, where I’m attending Dalton Discussion 11: The Renaissance of Main Group Chemistry. RSC discussion meetings are quite different from normal conferences: the speakers have submitted full papers of their work, and a collection of ‘pre-prints’ of all the papers is given to each delegate to read beforehand. Talks are then limited to about 5 minutes, with around 15-20 mins of discussion to follow. The papers are then published in one issue (in this case of Dalton Transactions) afterwards.

So, what has been discussed? A lot of pretty impressive main group chemistry, including some incredibly sophisticated Al and Ga cluster chemistry by Hansgeorg Schnoeckel. The size of some of these clusters are approaching nanoparticles, only these are molecularly defined – all with the same number of metal atoms. Ian Manners talked about his adventures with inorganic polymers, with alternating P and N rather than boring old carbon.

That’s actually a bit of a theme I’m finding: there’s a whole host of other elements out there apart from carbon and it’s their differences from, rather than their similarities to, carbon that makes the compounds unusual and interesting in so many ways.

There was an interesting and wide-ranging question posed by one of the chairs (Claire Carmalt): does chemistry (and main group chemistry in particular) need applications to justify funding, or should curiosity alone be enough? Most of the delegates thought curiosity was enough, and Chris Reed said that he often answers that question with ‘Ask me in 20 years!’ He made specific reference to some carboranes that he first made about 20 years ago, but is now using as extremely powerful yet gentle reagents. Someone from Los Alamos (whose name I didn’t catch) made the comment that applications demand blue-sky curiosity.

And a final mention must go to yesterday’s chair, Malcolm Chisholm, who reminded us of Mark Twain’s words that ‘the coldest winter he ever spent was a summer in San Francisco’.

Neil, in mercifully sunny Berkeley

Neil Withers (Associate Editor, Nature Chemistry)

Take me to your… workplace

In the proud tradition of exposing naive minds to new viewpoints and opportunities (like ‘Take your daughter to work day’, now apparently rebranded as ‘Take our daughters and sons to work day’) comes the more recent tradition of introducing dog-lovers and -haters alike to our furry friends (or, stated another way: today is ‘Take your dog to work day’).

While it would be interesting to ponder our increased desire to literally have our creature comforts with us at all times, what I am more amused by is wondering whether there would be any more impractical thing for a chemist to bring to work, as I have visions of energetic dogs running through labs, knocking things off counters with their crazy tails and licking up the resulting mess… Depending on the feline, I could see a ‘Take your cat to work day’ being equally disastrous, primarily because they could easily get up on the bench and not only push things onto the floor, but also bonk into TLC chambers or step on computer keyboards. The worst, though, might be ‘Take your lemur to work day’, as any creature that can climb up onto chemical shelves and throw bottles at you is not going to make friends.

Perhaps a better holiday would be ‘Take your chemist to work day’, where non-science people bring their science friends to ‘normal’ places, like offices and banks, and clothes stores. It would be a good chance for us science geeks to reacclimate to society at large, and perhaps we could spend some time telling them about all the exciting discoveries we’re making? And anyway, a lot less messy than a lemur in the lab.

Catherine (associate editor, Nature Chemical Biology)

NChem Research Highlights: cell metabolites, chocolate, and hydrogenation catalysis

Apologies to all those who logged in on Friday to read the witty and humorous NChem research highlight update but (for various reasons) they will now be brought to you on Mondays – although the highlights themselves will still go live on Fridays.

Another change this week: I’ve been called off the bench to liven things up (like Cesc Fabregas last night in Euro 2008) and replace Neil who is currently gallivanting on the west coast of America.

We all love yeast in the NChem office, (bread, beer, marmite) so before he left, Neil wrote about a mass spec method that has been developed for measuring the metabolites of single yeast cells.

We also all love chocolate and Steve had the pleasure of writing about work on its structure that could hopefully lead to prolonging its shelf-life.

The final paper is about catalysis; more specifically its about the search for cheaper ethylene hydrogenation catalysts.

Some very small versions of a couple of our favourite games caught our eye this week, first a micro version of the highly addictive game tetris and second, a superhydrophobic desktop hockey game.

And finally, if you run out of reagents in the lab this week you could always raid the liquor cabinet. Last week saw some seriously ingenious chemists make diamond out of tequila.

Gav

Gavin Armstrong (Associate Editor, Nature Chemistry)

Reactions – Harry Kroto

1. What made you want to be a chemist?

I was good at science and maths, art and tennis but had to get a job, and science in the 60s was a much better bet that art – I also lost too often at tennis. The number of career avenues open to kids in those days was much less then. I also had very good chemistry and art teachers. Wilf Jary and Harry Heaney at (Bolton) School and Mr Higginson for art. Harry Heaney subsequently left school teaching and became a Professor of Chemistry at Loughborough University

2. If you weren’t a chemist and could do any other job, what would it be – and why?

Almost certainly some field of graphic art and design. I do a lot of this now. Also, probably animation and science documentary – see www.vega.org.uk and www.geoset.info. I did have an interview with the BBC in 1964 but I wanted to live abroad so I decided to do a postdoc in Canada. They suggested I see them if and when I came back.

3. How can chemists best contribute to the world at large?

Chemists have made some of the most humanitarian contributions to society. Liebig (of condenser fame) advised the City of London on the chemical treatment of sewage and before this the Thames was so bad you died if you fell in it – it was so polluted. Crawford Long and others developed anaesthetics – imagine having a leg amputated without anaesthetics – as happened routinely before the 19th century (Image browse on Google Rowlinson’s drawings to get an idea).

Before 1942 when Florey, Heatley and Chain developed ways of making penicillin in large amounts (Fleming did not do any development on his discovery) blood poisoning routinely led to amputation and/or death. I am not sure but some estimates indicate that 70% of the world’s food is produced using fertilisers made by the Haber-Bosch process. What would the modern world be without modern polymers or had we not learned how to grow large crystals of silicon to make the wafers for computer chips. Aspirin and platinum anti-cancer drugs have been great contributions too as has Taxol developed by my FSU colleague Bob Holton. There have been so many wonderful contributions one can be proud of being a chemist.

Unfortunately some chemists have made anti-humanitarian contributions. I was terribly disappointed when I learned that Louis Fieser – who had written the fantastic text book on Organic Chemistry (Fieser & Fieser) that I had bought when I was a kid at school and had read from cover to cover – had invented napalm. I try to encourage young students of science to distance themselves from this sort of application – I do not call it science – and focus on humanitarian contributions. Haber’s reputation has also been tarnished by his development of nerve gas. I ask young people would they not rather be almost unknown heroes such as Norman Heatley who did all the key penicillin experiments and has saved millions of lives and limbs.

4. Which historical figure would you most like to have dinner with – and why?

I have relocated to the US and learned a lot about the birth of the US and have developed a great admiration for the so-called founding fathers. I would like to discuss their concerns and how they formulated the US Bill of Rights and the US Constitution – fantastic creations. I would like to have dinner with three of them Thomas Paine who lived for a while in my home town Lewes and wrote the Rights of Man; Benjamin Franklin a scientist and really the first American – who lived in London for nearly 20 years and was terribly treated just before the Revolution and Thomas Jefferson who recognised that there can be no democracy if Church and State are not separate. This latter point is of great importance today.

5. When was the last time you did an experiment in the lab – and what was it?

I must admit that I have so many commitments that unfortunately my co-workers tend to do most of the hands-on experimental work now though I occasionally have been involved with electron microscope observations.

I have not had a lab for the last 3 years as I had to retire from my position at Sussex. I have just got a beautiful lab in a great new building at Florida State University. The last time I did an experiment all by myself with no help from anyone else!!! was in 1990 when I at last had a sample of C60 in my hands. In our C60 discovery paper in 1985 we had conjectured that C60 might be a superlubricant. After all, we thought(!!!) that as flat graphite is a lubricant – round graphite should be even better. When I took the sample and pressed it with a spatula on a glass slide it behaved like grit – disappointingly. I could not understand this until I learned that graphite is not a lubricant unless air and water intercalate between the layers – for instance it cannot be used at high altitude or on the space shuttle. I discovered that the text books are incorrect on this – the interlayer forces are not weak and graphene layers do not slide over each other in vacuo.

6. If exiled on a desert island, what one book and one CD would you take with you?

I think I would take an introduction to Quantum Electrodynamics (maybe Feynman’s) as I would want to go the next step on from Quantum Mechanics which I vaguely know a bit about already – at least enough to analyse molecular spectra and fool some people into thinking I understand QM.

If I could also take a guitar I think I would take a James Taylor LP so I could try to improve my ability – which is very limited to play the guitar. I guess it would have to take his (Live) album or Greatest hits album as I would want Carolina in my Mind as well as Sweet Baby James which are on his first two albums.

Sir Harry Kroto is in the Department of Chemistry and Biochemistry at Florida State University, and works on the mechanisms of self-assembly at nanoscale dimensions, the species which exist in carbon vapour – there are hundreds and at least 5 families, the stabilisation of small fullerenes and nanotube applications.

Non-deep thoughts by Catherine Goodman

It’s amazing how discerning our eyes are. I was just looking at the cover of our July issue, and there are some chemicals on it; though they are just long white chains, it’s clear to me that they aren’t just regular chains… can you all spot the modification? If not, the related paper will give you a pretty good hint.

Some of the other goodies in this issue (from the strictly chemistry point of view) include the synthesis of neopeltolide and an analog of leucascandrolide A, which were then used in some biology experiments that you may or may not be interested in, and the characterization of some isotopically-labeled intermediates that tell us about what some protein or other is doing. There are some other things too, about stem cells and the discovery that humans can reduce nitrate, but they’re awfully biological. Maybe you shouldn’t even look at them. In fact, I’ve decided you’re not allowed to look at them. So don’t. I mean it – stop it right now.

You can look at the report on the recent ASBMB meeting, if only to get psyched up for whatever meetings you might be going to this summer. I’m looking forward to the ACS, if only because I don’t have to pay a huge sum to get there on a plane. How are travel costs affecting you? Have you had to turn down any fun opportunities for lack of funds? Do you have any good suggestions for how to get around it (barring repeats of the recent drive from DC to New Orleans)?

Ok, back to work. These issues don’t make themselves, you know…

Catherine (associate editor, Nature Chemical Biology)