Reactions – Glen Miller

1. What made you want to be a chemist?

When I was 14 or 15, I was certain that I would become a journalist. By this age, I had already gained experience working at a local newspaper as a sports reporter. I was also beginning to research journalism programs at a number of colleges. My high school guidance councilor suggested that I take chemistry to “make my college applications more competitive” and the rest, as they say, is history. My high school chemistry teacher (Mr. Donohue, East Syracuse-Minoa High School) was superb and I knew almost immediately that chemistry was my calling. Another real turning point came in college when, as a chemistry major, I began doing research in Professor Petr Zumans’ laboratory. This experience opened up a whole new world for me, one which continues to excite me many, many years later.

2. If you weren’t a chemist and could do any other job, what would it be – and why?

Given my previous response, you’d probably think that my answer would be journalism. However, I think that archeology would be my number 2 choice. Over the years, I’ve acquired a great appreciation for history. The idea of pursuing clues that help to unravel ancient history is really quite appealing to me. Of course, three months of digging in a hot desert could very well change my mind.

3. How can chemists best contribute to the world at large?

I think the simple answer is to be excellent. Chemists are a fairly bright lot. We work on very challenging problems that impact many fields including medicine, materials, energy, etc. It is absolutely inconceivable that chemists will not play a large role in providing long-lasting solutions to the major problems that face us (i.e., diseases, limited fossil fuels, global warming and climate change, hunger, etc.). The best way for us to contribute is by being excellent at what we do. After all, we surely can’t expect much from the physicists 🙂

4. Which historical figure would you most like to have dinner with – and why?

John Adams, 2nd President of the US. David McCullough’s biography of John Adams was a real eye-opener. It fascinated me to no end. I would love to spend an evening picking John Adams’ brains, preferably at a time after his presidency had ended. He was a remarkable visionary with an amazing intellect. He raised and debated fundamental questions about governance and human rights and prosperity – questions that are still very relevant today. By the way, if Abigail Adams happened to join us, all the better.

5. When was the last time you did an experiment in the lab – and what was it?

Probably six months ago when I attempted to demonstrate that carbon nanotubes could be transferred from one substrate to another using simple mechanical forces. I was surrounded by several students who were (1) amazed to see me in the lab and (2) laughing because they thought that this could never work. Fortunately for me, AFM images revealed a clean transfer. For the most part, I’m smart enough to leave the experiments to the people that know what they’re doing.

6. If exiled on a desert island, what one book and one CD would you take with you?

For the book, I’d probably take the latest edition of March’s “Advanced Organic Chemistry” from which I could draw inspiration while drawing chemical structures in the sand. For the CD, I’d take my copy of “Faith Rewarded: The Historic Season of the 2004 Boston Red Sox”. This way, even if I was never rescued, I could continuously relive the greatest comeback in the history of sports by the greatest team in the history of sports. And although I draw no pleasure whatsoever from watching the misery of others, this monumental feat, as it turns out, also marks greatest collapse in the history of sports by another franchise which I refuse to name,… ever. New Hampshire, by the way, is just one hour north of Boston.

Glen Miller is in the Department of Chemistry and the Materials Science Program at the University of New Hampshire and works on a number of projects at the intersection of organic chemistry and nanoscience. These typically involve fullerenes and carbon nanotubes.

I’m into something good

The joy of this job is that we are constantly reading about new research, whether its newly submitted manuscripts or just keeping up with current literature. The downside, of course, is that all of these things are written in prose. Where’s the poetry in science, I ask? (as did Feynman) You can find one recent example in a News & Views in our July issue, but I think this is only the start of something good, as Herman’s Hermits told us.*

Since all cultural revolutions have to start small, I thought I would suggest the idea of chemistry haikus, since a) they don’t have to rhyme, b) they aren’t very long (remember the 5-7-5 motif?), and c) they don’t have the tendency for the downward spiral in the same way that limericks do…

The idea is easy. Instead of writing down that your reaction went with 0% yield, try this:

Water gets in and

Messes up everything. Bah!

It’s time for a break.

Or, when your rotation student tends your reaction overnight and you return to a mess, sum it up with these few words:

All at once I find

My nice halogenation

Didn’t work at all

Finally, for those of you bioorganic folks, I think the starter ‘Oh stupid peptide’ could take you a long way… For example:

Oh stupid peptide,

why won’t you make a helix?

It isn’t that hard

Oh stupid peptide,

please come off the resin now.

TFA ran out.

You see how it works. So, with these suggestions as your rallying battle cry, go forth and be poetic! And let me know what good ideas you come up with to describe your scientific adventures.

Catherine (associate editor, Nature Chemical Biology)

(*ed’s note, 01/31/08: a reader who is a more knowledgeable music fan than I am (or just not as inept at using the ‘interweb’, perhaps) pointed out that this song was actually by this group, not the Beach Boys, as previously indicated. Oops!)

Fashion

While standing on the tube platform this morning (trying to ignore the general unpleasantness associated with London’s public transport system), an advert caught my eye. It featured a model wearing a T-shirt with a periodic table on it. For a brief moment, I was overcome with the notion that chemistry had become fashionable, possibly even sexy.

Further evidence of the chemistry-fashion interface is, admittedly, rather scarce. A few years ago, a manufacturer of safety glasses came up with a new streamlined design, incorporating brightly coloured arms and so on. I thought this was pretty ridiculous – it’s very difficult to make safety equipment look trendy. But they went down a storm with my colleagues. I was even criticised during a safety inspection for not wearing the ‘cool’ version of the safety specs (and not for safety reasons – this is not a joke…)

Other than that, my university’s chemistry society had a few rather sad T-shirts emblazoned with slogans such as “Chemists have solutions” and “Tickle a chemist and see the reaction”. But who knows? Maybe chemical elements could become the new iconic brands? Fashionistas wearing ‘Sb’ logos could look down on their less up-to-date friends, who are still wearing last year’s ‘Cs’ jeans. Where would it all end? Any other ideas?

Andy

Andrew Mitchinson (Associate Editor, Nature)

Whiskey in the jar

On Wednesday night (June 27th), Nature Network Boston will be hosting their first ‘pub night’ at Tavern in the Square (in Central Square, Cambridge). Corie Lok, the editor of Nature Network Boston, recently blogged about this event, which will be “your chance to meet other scientists from the Boston area, including other members of and bloggers on Nature Network Boston and a few people from Nature’s Cambridge office…”

The pub night officially starts at 6:30 PM, and I’ll be there for an hour or so; I think Catherine said that she’s planning on being there for a little while too. So if you’re in Cambridge that night, please swing by and say ‘hello.’ Make sure you come early, as Corie’s buying the first 30 people a free drink…

Hope to see you on Wednesday night!

Joshua

Joshua Finkelstein (Senior Editor, Nature)

The NIHghts who say ‘no’

Apologies to our international readers for the U.S.-centric post, but the National Institutes of Health announced earlier today that PAR-07-353, a grant involving Cheminformatics Research Centers, has been canceled for “programmatic reasons.” For those of you who haven’t heard of the Cheminformatics Research Centers, they are part of the Molecular Libraries Roadmap Program (MLP), which is

an integrated set of initiatives aimed at developing and using selective and potent chemical probes for basic research … [The MLP] was proposed to introduce high-throughput screening approaches to small molecule discovery, formerly limited to the pharmaceutical research industry, into the public sector… [and] is made up of the following major components: (1) access to a library of compounds (Molecular Libraries Small Molecule Repository); (2) access to bioassays provided by the larger research community; (3) support for the development of breakthrough instrumentation technologies; (4) access to a network of screening and chemical probe generation centers (MLPCN) where assays are screened and probe development is undertaken; (5) Pubchem, the primary portal through which the screening results of the MLPCN are made public and (6) the Cheminformatics Research Centers (CRCs) with multiple roles focused on high-level data analysis and dissemination with a focus on developing new understanding of the cellular processes (genes and pathways).

One reason why this is so surprising is because the grants were due next week (June 28th). I imagine the timing of this decision (and the decision itself) is bound to upset a number of people in this community, especially since many applicants were probably working around the clock to get their grant submitted before the (now non-existent) deadline…

Does anyone know more about this story or why the grant was canceled?

Joshua

Joshua Finkelstein (Senior Editor, Nature)

Reactions – Catherine Goodman

[In lieu of profiles, the contributors to this blog have decided to do their own Reactions pieces…]

1. What made you want to be a chemist?

Like Josh, I didn’t get interested in chemistry until quite late in the game. My high school science classes were not very inspiring, but they were also sufficiently painless that I wasn’t averse to taking more when I got to college. My freshman general chemistry class, then, got things moving: It was taught in the Socratic method by the best teacher ever, John Hutchinson. While the rest of the class was great, my ‘eureka’ moment came during a lecture about how soap works… as stupid as it sounds, the idea that physical processes could be explained in such a meaningful and elegant way really set me on the scientific path.

2. If you weren’t a chemist/Nature Editor and could do any other job, what would it be – and why?

Well, I’ve been saying for a long time that I wish someone would pay me to read things, so if I couldn’t have this job, the other obvious choice is as an editor for a ‘normal’ publisher where I could read silly things (i.e., fiction). The other other (i.e., non-geeky) obvious choice would be as a dancer, although I would have to get back in shape (ahh, guacamole, the plague of my exercise plan!).

3. How can chemists best contribute to the world at large?

Without getting too negative, I think that many people live their lives without thinking things through, either in terms of their consequences (i.e., ‘it doesn’t matter if I throw this trash on the ground’…) or in how they will affect people around them (hmm… not sure I should get into this one, but let’s say I do not see eye-to-eye with Bush’s policies…). I like that scientists, as a whole, seem to be more willing to think about things carefully and act accordingly. Thus (although I guess this isn’t specific to chemists), an important potential contribution is to help people think more often.

4. Which historical figure would you most like to have dinner with – and why?

Do they have to be dead? I would say Jon Stewart. I simply cannot imagine a more hilarious evening.

5. When was the last time you did an experiment in the lab – and what was it?

Last spring (May ’06) – I was trying to figure out if my beta-peptides had structure or not, and spent a few frustrating days on the CD. The last time I did an actual chemical experiment was shortly before that – homologating alpha amino acids to the beta compounds with diazomethane. I am proud to say there were no explosions.

6. If exiled on a desert island, what one book and one CD would you take with you?

I am, as my sister would say, an easy reader, so this is a tough one! Since I know I love it, and it’s long enough to take more than ~a day to read (and I could use it to further improve my Japanese), I would probably take Shogun, by James Clavell. (Josh thinks I should point out that I got this book for 25 cents, amidst a used-book-sale binge of 300 books. Fortunately they all cost ~25 cents.) Otherwise I’d take the complete works of Shakespeare. A CD… probably Crash, by Dave Matthews Band. Unfortunately, my favorite time to listen to that CD is while driving, which doesn’t work out so well for being on a desert island… can I have a (CD-equipped) dune buggy too?

Catherine Goodman is an Associate Editor for Nature Chemical Biology and a regular contributor to the Sceptical Chymist.

CFCs: Confessions of a former chemist

[Editor’s note: over the next few months we will feature guest bloggers from a range of backgrounds and hopefully some of these posts will turn into regular series… first up is Mushy, a former chemist who has left it all behind for the bright lights of the City!]


Posted on behalf of Mushy:

My name is Mushy, and I am a recovering chemist – it’s been over 6 years since I ran my last chromatography column. I have been asked to write on the Sceptical Chymist every now and then to give the views of an ex-chemist.

After completing a PhD in supramolecular chemistry in the US, and following a rather meandering job path, the undisputed highlight of which was months of unemployment, I now work in IT in the City of London.

After finishing Uni, I was certain that I didn’t want to work in chemistry. I had something of a long job search, most of which was spent mired in a Catch-22 where I was not qualified for the jobs which I wanted, and the only jobs for which I was qualified, I didn’t want. In spite of a few negative experiences with – sour grapes notwithstanding – short-sighted companies which only wanted people with very specific degrees, nothing could be further from the truth. The skills I learned as a chemist – the methodical approach, the empiricism, the confidence, the flawless proff-reading – have served me well in an industry in which I had no experience at the outset.

I suppose that that’s where I’ll start summing up my inaugural post.

At work, I’ve never been asked to explain a [4+2] cycloaddition. The astrophysicists have never been asked their opinions on the Hubble constant. The chemical engineers have never become embroiled in heated debates about theoretical plates. The molecular biologists have never orated on the pros and cons of gel electrophoresis. The people who studied golf course management – well – they didn’t get the job. What we all do use every day of our working lives, though, is the thought process that got us into science in the first place, and the excitement of finding out new facts and methods. That’s the most transferable of all skills.

Man in the mirror (on the moon)

In the words of my news editor, I’ve had a day geeking out on chemistry, and it’s been great. Two papers in Nature this week about newsworthy chemistry (it’s all newsworthy, I hear you cry….).

I’m not sure which was my favourite – as someone who did their masters degree doing organometallic synthesis in ionic liquids, I loved the latest application of the erstwhile green solvents – to support a liquid mirror on the moon. (News story here and paper here.) And the accompanying News and Views article focuses on ionic liquids, rather than going to the moon (which my news piece hangs on). It was a bit of a leap of imagination for whoever thought about using ionic liquids in this way, but a great new application for them. I’m impressed. Of course, we have to colonise the moon first – a minor point.

The second news story from a second paper was about another subject I have delved into in the past – biofuels (see feature). This latest research effort uses acid-hydrolysis to turn fructose into 5-hydroxymethylfurfural, and then a ruthenium/copper catalyst to turn that into 2,5-dimethylfuran (DMF). DMF has the potential to be a far, far better biofuel than ethanol. All that is required now is the funding to develop the processes.

Outnumbered

Love ‘em, hate ’em? It’s hard to ignore them – 2006 journal impact factors were released by Thomson yesterday.

Expect to be bombarded with publishers telling you how much better their journals are than in previous years. I feel a little left out, Nature Nanotechnology won’t get it’s first impact factor until this time next year, until then you’ll just have to take my word that we’re good!

If you care (and have access), check out your favourite journals and how they did at Thomson’s ISI Web of Knowledge, under Journal Citation Reports…

More generally – how important is a journal’s impact factor to you (or your advisor)? Does it influence where you publish, or do only publishers care about these metrics?

Stuart

Stuart Cantrill (Associate Editor, Nature Nanotechnology)