Whiskey in the jar

On Wednesday night (June 27th), Nature Network Boston will be hosting their first ‘pub night’ at Tavern in the Square (in Central Square, Cambridge). Corie Lok, the editor of Nature Network Boston, recently blogged about this event, which will be “your chance to meet other scientists from the Boston area, including other members of and bloggers on Nature Network Boston and a few people from Nature’s Cambridge office…”

The pub night officially starts at 6:30 PM, and I’ll be there for an hour or so; I think Catherine said that she’s planning on being there for a little while too. So if you’re in Cambridge that night, please swing by and say ‘hello.’ Make sure you come early, as Corie’s buying the first 30 people a free drink…

Hope to see you on Wednesday night!

Joshua

Joshua Finkelstein (Senior Editor, Nature)

The NIHghts who say ‘no’

Apologies to our international readers for the U.S.-centric post, but the National Institutes of Health announced earlier today that PAR-07-353, a grant involving Cheminformatics Research Centers, has been canceled for “programmatic reasons.” For those of you who haven’t heard of the Cheminformatics Research Centers, they are part of the Molecular Libraries Roadmap Program (MLP), which is

an integrated set of initiatives aimed at developing and using selective and potent chemical probes for basic research … [The MLP] was proposed to introduce high-throughput screening approaches to small molecule discovery, formerly limited to the pharmaceutical research industry, into the public sector… [and] is made up of the following major components: (1) access to a library of compounds (Molecular Libraries Small Molecule Repository); (2) access to bioassays provided by the larger research community; (3) support for the development of breakthrough instrumentation technologies; (4) access to a network of screening and chemical probe generation centers (MLPCN) where assays are screened and probe development is undertaken; (5) Pubchem, the primary portal through which the screening results of the MLPCN are made public and (6) the Cheminformatics Research Centers (CRCs) with multiple roles focused on high-level data analysis and dissemination with a focus on developing new understanding of the cellular processes (genes and pathways).

One reason why this is so surprising is because the grants were due next week (June 28th). I imagine the timing of this decision (and the decision itself) is bound to upset a number of people in this community, especially since many applicants were probably working around the clock to get their grant submitted before the (now non-existent) deadline…

Does anyone know more about this story or why the grant was canceled?

Joshua

Joshua Finkelstein (Senior Editor, Nature)

Reactions – Joshua Finkelstein

[In lieu of profiles, the contributors to this blog have decided to do their own Reactions pieces…]

1. What made you want to be a chemist?

I was a bit of a ‘late bloomer’ when it came to chemistry: I didn’t own a chemistry set when I was growing up or run reactions in my garage. And I didn’t really enjoy high school chemistry classes (though I liked that feeling you get after successfully balancing a complex chemical reaction…) But I had an amazing AP chemistry teacher in high school, so I went into college with an open mind. When I got there, I was drawn to organic and biological chemistry: I thought it was so cool that a chemist could (design and) synthesize a biologically-active organic molecule that could be used to tease apart a complex cellular process or could be developed into a drug.

2. If you weren’t a chemist/Nature Editor and could do any other job, what would it be – and why?

Like Andy, I probably would have been a musician – I play drums, jazz piano, various percussion instruments, and sing a bit. (I’m trying to learn how to play guitar, but don’t think my fingers are the right length/shape – or maybe I just need to practice more?) I played in a few bands in graduate school (which really helped keep my spirits up when my chemistry wasn’t working), and I miss the feeling you get when you’re playing music with close friends in a dirty/dusty basement…

3. How can chemists best contribute to the world at large?

The simple answer is to work on an important scientific problem that isn’t being adequately addressed by other chemists – easier said than done, though… I guess an important question to constantly ask is “why am I doing this experiment/project?” As long as you know the answer to that question, then you are probably “contributing to the world at large” – if you can’t think of a good/satisfying answer, maybe it’s time to change projects?

4. Which historical figure would you most like to have dinner with – and why?

If I had to choose a scientist, I’d probably invite Linus Pauling or RB Woodward to dinner – I’d be interested in hearing what they think about all the things scientists have discovered in the last few decades. If I could choose any historical figure, I think I’d invite Oscar Wilde or John Coltrane – I imagine Wilde would be hilarious in person and I’d love to hear Coltrane talk about music and tell stories about the jazz scene in the 50s and 60s…

5. When was the last time you did an experiment in the lab – and what was it?

Several years ago – I can’t remember exactly what it was, but it involved DNA glycosylases…

6. If exiled on a desert island, what one book and one CD would you take with you?

I think I’d want to bring something I’d read before/knew I liked – so I’d probably go with Tolstoy’s Anna Karenina or Eco’s Foucault’s Pendulum. As for music, I don’t think I could survive if I only had a single CD – does a mix CD count? If so, I’d burn one that had the second movement of Beethoven’s 7th Symphony, John Coltrane’s Giant Steps, Dizzy Gillespie’s A Night in Tunisia, Beck’s Tropicalia, Life In A Glass House from Radiohead’s Amnesiac and/or Morning Bell from Radiohead’s Kid A, Stevie Wonder’s Superstition, and a few other tracks… (Thank goodness for iPods…)

Joshua Finkelstein is a Senior Editor for Nature and a regular contributor to the Sceptical Chymist.

The weight

There’s an interesting news piece over at news@nature.com that caught my eye – a team led by Helge Riemann at the Institute of Crystal Growth is trying to generate a ‘pure’ sample of crystalline silicon-28:

The new barbell-shaped crystal, which weighs 5 kilograms and was completed on 23 May by Riemann’s team … is nearly isotopically pure. It was made from Russian source material, whose silicon was 99.994% pure silicon-28.

A standard kilogram is currently calibrated using the “”https://www.bipm.org/en/scientific/mass/pictures_mass/prototype.html">international prototype," which “”https://www.bipm.org/en/scientific/mass/prototype.html">was manufactured in the 1880s [from] an alloy of 90% platinum-10% iridium" and is housed in the Bureau International des Poids et Mesures in France. Over time, the loss and/or gain of atoms from the international prototype may have altered its weight – the news story suggests that it might be off by 0.1 milligrams/0.01% (but I couldn’t find any additional information to verify that statement…)

Making this (two-million euro/2.7-million USD) piece of silicon was no easy task:

The researchers spent six months eliminating contaminating elements by repeatedly melting the silicon in an apparatus that does not touch the material. The resulting crystal is thought to contain one foreign atom to every 10 million atoms of silicon.

Talk about a pure sample…

Joshua

Joshua Finkelstein (Senior Editor, Nature)

Living in a material world…

I was out at the pub last night with a few other editors, and one of my colleagues mentioned that an editor from Nature Materials is leaving the company (and the country) – while she’ll be definitely be missed by all, this means that Nature Materials is searching for a new associate editor to join their team:

We are particularly interested in applicants with expertise in bio-inspired, biomedical and biomolecular materials, but we would welcome applications from outstanding candidates in any area of materials science.

The ideal candidate should have a PhD and preferably postdoctoral experience with a strong research record. The successful candidate will play an important role in determining the representation of their field in the journal, and will work closely with the other editors on all aspects of the editorial process, including manuscript selection, commissioning and editing of Reviews and News & Views, and writing for the journal. A key aspect of the job is liaising with the scientific community through laboratory visits and international conferences.

If you’re interested in the position (which will be based in the London office – with Stuart and Andy), you’ll need to apply soon – applications need to be in by June 4th…

Joshua

Joshua Finkelstein (Senior Editor, Nature)

London calling

Every six months or so, I pop over to England to catch up with my colleagues in our London office (NPG’s largest office). I love visiting this city, and it’s not just because I get to use words like ‘skint’ and eat fantastic Indian food every night…

But I was thinking about how difficult it must be for people who move to a new country to start their Ph.D.s/post-docs/jobs – in addition to adjusting to a new lab/co-workers (which can be difficult even if you’re working in a familiar city/country), you have to learn how things are done/how things work in your new environment. As trite as it sounds, so many things can be so different.

For example, I lived in London for two months when I started at Nature, and I’m embarrassed to say that I had to dig out the manual for my combo washer/dryer to figure out how to operate it. (I thought I was doing something wrong because my clothes never came out 100% dry – it turns out that the machine in my apartment didn’t use heat to dry the clothes, just an extended spin cycle…) Even going to the pub can be problematic: we had a German post-doc in our lab who frequently forgot to bring his passport when we went out for drinks. Despite the fact that he was in his mid-30s (and clearly looked old enough to drink in the U.S.), he had a difficult time convincing waiters/waitresses to serve him without ID…

For those of you who changed countries when starting your Ph.D./post-doc/job, I was wondering what little differences were the most frustrating for you? And for those of you who are living in a city/country you know well, how do you help your new co-workers adjust to their new environment? (For example, I’ve heard that some schools/labs distriubte packets that contain local information, FAQs, etc. – are these useful/helpful?)

Joshua

Joshua Finkelstein (Senior Editor, Nature)

I’d like to buy the world a Coke

The office coffee machine broke down this morning, so I’ve been using Coca-Cola to fight off the postprandial dip. I rarely drink soda (aside from the occasional Cuba Libre), so I’m usually the last to know about (crazy) new kinds of soda. But there’s a case of Diet Coke Plus in our office refrigerator – you might not have seen it in your local supermarket, but it’s a new version of Diet Coke that contains several vitamins and minerals:

Each eight-ounce serving of Diet Coke Plus provides a good source of Niacin (vitamin B3), vitamins B6 and B12, zinc and magnesium (15% Daily Value [DV] for Niacin, B6 and B12, 10% DV for zinc and magnesium).

Great news, no? Now you don’t have to take that pesky multi-vitamin every day. Just have a few cans of Diet Coke Plus and you’ll be all set…

Not a fan of Diet Coke? Not a problem: PepsiCo is responding with the launch of Tava this fall, which will contain “”https://www.iht.com/articles/2007/03/07/business/soda.php?page=1">vitamins B3, B6 and E, and chromium." (Chromium?)

I’m just waiting for them to combine soft drinks with OTC medication: “have a hangover and can’t stay awake at your morning meeting? Try new Coke NSAID – it comes in two flavors: cherry aspirin and vanilla ibuprofen…” Yum…

Joshua

Joshua Finkelstein (Senior Editor, Nature)

Pour some sugar on me

In this week’s issue of Nature, there’s an Insight – a special collection of six or seven related review articles – on Glycochemistry & Glycobiology. In this particular Insight, there are seven review articles:

Chemical glycosylation in the synthesis of glycoconjugate antitumour vaccines from Galonic & Gin

Unusual sugar biosynthesis and natural product glycodiversification from Thibodeaux, Melancon, & Liu

Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins from Hart, Housley, & Slawson

Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins from Varki

Heparan sulphate proteoglycans fine-tune mammalian physiology from Bishop, Schuksz, & Esko

Exploiting the defensive sugars of HIV-1 for drug and vaccine design from Scanlan, Offer, Zitzmann, & Dwek

Synthesis and medical applications of oligosaccharides from Seeberger & Werz

There’s also a paper from van Kasteren et al. (with a News & Views from Grotenbreg & Ploegh) describing a new chemical tagging approach that can be used to add multiple sugars to bare protein scaffolds (i.e., proteins that were over-expressed and purified from bacteria). (You may have also noticed Wang et al‘s paper in last week’s Nature, so it looks like April may be the sweetest – and not the cruelest – month after all…)

As I wrote in the editorial that accompanies the Insight, scientists generally shy away from carbohydrates – I barely remember learning about them in my undergraduate years and spent little time thinking about them during graduate school. But now it seems like the field is exploding: everywhere you look there’s an interesting paper about carbohydrate chemistry and biology.

So with that in mind, we’ve put together this collection of review articles to celebrate chemists and biologists working with carbohydrates… We hope you enjoy them!

Joshua

Joshua Finkelstein (Senior Editor, Nature)

On the streets of Philadelphia

You may have already seen this news story in C&EN about a recent trial in Philadelphia: Merisant (the company that produces Equal and NutraSweet) has sued McNeil Nutritionals (the company that makes Splenda) because Merisant doesn’t think it’s fair that Splenda’s marketing campaign includes the phrase “made from sugar, so it tastes like sugar.”

This is the kind of advertising campaign that makes most chemists cringe, and – though this may sound like a petty dispute between two rival companies – I think we need to hold companies accountable for exploiting the general public’s lack of scientific knowledge. Unfortunately many people will think: Splenda is not sugar, but it is made from sugar – so it must be safe, right? (Wasn’t palytoxin made from sugar?) Though this sort of ad campaign wouldn’t work on many scientists, it certainly worked on the general public: “”https://pubs.acs.org/cen/news/85/i16/8516notw5.html">sales of Splenda were weak in 2001, when McNeil launched an ad campaign saying the sweetener is made from sugar and including the phrase ‘but it’s not sugar.‘" Since then, “Splenda has eclipsed Equal in the lucrative artificial sweeteners market” – and it’s not like Merisant can counter with an ad campaign, saying that Aspartame’s “made from phenylalanine, so it tastes like phenylalanine”…

It should be an interesting trial, as it’s bound to have “”https://www.boston.com/business/articles/2007/04/09/sweet_like_sugar____but_its_not_sugar/“>phalanxes of neurobiologists and chemists as expert witnesses.” (As an aside, I guess that the answer to Stuart’s question is ‘a phalanx of chemists’…) And the best part is that it’s a jury trial, so anything can happen

Do you think they’ll use voir dire to exclude people who prefer natural sugar or are loyal to one of the two brands? Maybe I should offer my services, as I’m pretty indiscriminant when it comes to sweetening my coffee…

Joshua

Joshua Finkelstein (Senior Editor, Nature)