SciArt scribbles: The mellifluous gene editor

Many scientists embrace the artistic medium to infuse new ideas into their scientific works. With science-art collaborations, both artists and scientists challenge their ways of thinking as well as the process of artistic and scientific inquiry. Can art hold a mirror to science? Can it help frame and answer uncomfortable questions about science: its practice and its impact on society? Do artistic practices inform science? In short, does art aid evidence?

Nature India’s blog series ‘SciArt Scribbles’ will try to answer some of these questions through the works of some brilliant Indian scientists and artists working at this novel intersection that offers limitless possibilities. You can follow this online conversation with #SciArtscribbles .

When Debojyoti Chakraborty isn’t engrossed in gene editing experiments in his lab, you will find him rehearsing for his next sitar recital. A senior scientist at the CSIR Institute of Genomics and Integrative Biology in New Delhi, Debojyoti has a parallel career as a performing sitarist, trained in the Maihar school of music. The musician scientist tells us how CRISPR Cas9 and raga megh beautifully balance his creative energies.

Debojyoti Chakraborty{credit}Ashish Gupta{/credit}

Very recently, we lost one of the doyens of Indian classical music, the surbahar and sitar player Shrimati Annapurna Devi. In times when terms like ‘legend’ and ‘irreplaceable’ are used indiscriminately, Annapurna Devi is perhaps one of those artists whose lifelong devotion to music will compel us to remember her as a ‘musician’s musician’ long after she is gone.

Music, like science, is a journey of a lifetime and for the few fortunate people like me who have just begun to scratch the surface of both, they are a constant source of satisfaction and gratification.

I have been learning and playing the sitar for more than 24 years, way longer than I have been in science as my main profession. Perhaps the excitement of pursuing two fields that are seemingly infinite in scope and yet extremely rewarding for the creative mind is what still drives me to pick up my instrument for practice after a long day in the lab. Needless to say, science on most occasions for a young group leader is an extremely frustrating venture — juggling grants, research and administration. Music is thus not only a source of comfort but also a medium to vent out the nervous energy, a constant companion of the scientist.

The sitar is a seven stringed instrument (with thirteen additional sympathetic strings) that requires several parts of the body to work in unison: the vigorous right hand movements that evoke the sound, the gliding left hand that pulls on the main string and above all the continuous brain stimuli which channelise inputs from both into the shape and form of a raga or the melodic interpretation of a mood.

[Watch Debojyoti perform raga Khamaj at the Indian Embassy in Berlin, accompanied by Pt. Debaprasad Chakraborty and Ashis Paul: https://youtu.be/om5bR9eNj3M]

In many ways, there is a lot of consonance between the job of a researcher and a musician — both involve multitasking at various levels. Thus marrying music and science has traditionally not been difficult for serious enthusiasts.

For me, the initial phase of learning was marked by the general unwillingness to practice but half-hourly candy bribes from my father made sure I complied. It was only much later, when I really began to like the sounds I produced, that self-motivation crept in and I could spend long hours without feeling any stress. Several years down the line during my PhD, the belief that with persistence my project will take shape helped me wade through those doctoral blues. Music thus teaches life lessons that come handy in various situations.

For a musician, listening to good music is of paramount importance. Just like a toddler learns new words by continuously repeating them, listening to various improvisations and compositions on the same melodic structure or percussive element allows a classical musician to develop a refined, original and personal style. A lifelong devotee of masters like Ustad Ali Akbar Khan, Pt. Nikhil Banerjee and Ustad Vilayat Khan, I grew up buying records and hearing them every night. I attended nightlong music conferences and tried to emulate everything about the artists — from their stage mannerisms to the color of their kurtas! This helped when I later became a performer myself. After all, an artist is a package of creativity and every aspect of that package needs to be perfectly aligned to deliver a memorable performance.

Similarly, in my scientific pursuits I have been fortunate to meet scholars and laureates who have shaped our understanding of the natural sciences. In most of these meetings, I felt that humility, devotion and a child-like excitement for knowledge are hallmarks of musical or scientific greats, regardless of their age or nationality. Once I spent an hour with the outstanding dance guru Pt. Birju Maharaj, listening to compositions that he learnt forty years ago. The glee in his eyes as he recounted the tunes told me how much he loved his art form and how much pleasure he still derived. It was no different from the expressions of Edmond Fisher, the Nobel laureate, whom I had the good fortune of meeting in Lindau.

My training in both music and science has given me access to the international and truly plural nature of both fields. At the Technical University of Dresden, I have worked as a guest researcher in music, trying to model Indian ragas mathematically with musician scientists from Europe. We still tour as the musical group Dhun. Our compositions universal, an example being the interpretation of a melody by Rabindranath Tagore that has the influence of the Scottish highlands and is set to notes of raga Gaud Sarang.

The time I spent in learning from European musicians has been enriching and filled with great camaraderie. This is in stark contrast to the somber and introspective nature of pure classical performances that I give. Musical associations are creative exercises that build long distance bonds just like scientific collaborations. At least on one occasion, it had also helped me finance my stay in a foreign country when transitioning between jobs.

My area of research is focused on developing better gene editing strategies using CRISPR Cas9 to target monogenic disorders like sickle cell anemia in Indian patients. The field of genome editing is fast paced and of late, balancing research, fatherhood and music has been challenging. However the support and encouragement of close family members and friends keeps me motivated to play and perform.

Being in science makes me pursue music for its aesthetic beauty and not purely for financial reasons. This is a refreshing thought to wake up everyday to since music, like most professions, comes with cut throat competition that often undermines its inherent beauty and soulful character. Being in science also makes me work with exceptional colleagues who appreciate creative art and share similar passion.

It has been an invigorating journey so far.

[Debojyoti Chakraborty can be contacted at debojyoti.chakraborty@igib.in]

Suggested reading:

SciArt scribbles: The molecule painter

SciArt scribbles: Coupling creation and analysis with collages

SciArt scribbles: Technology to aid dance

SciArt scribbles: Music to tackle PhD blues

SciArt scribbles: Playing science out

Artists on science: scientists on art

 

Writing a postdoctoral fellowship grant

Are you in your final year of PhD, struggling to tie up the loose ends of your thesis? Also dodging the elephant in the room — “what next”?

In this guest post, Nazia Nasir, a visiting research fellow at the University of Leeds, United Kingdom, shares why ignoring the elephant won’t make it disappear. And what you must do if you decide to write that postdoctoral fellowship grant.

Nazia Nasir

Stop all your work, grab a coffee, and devote some time to the all-important question — if I want to continue in academics, do I want to look for open positions or write a fellowship grant?

Here’s why and how I took up the latter option.

Why opt for a fellowship?

If you wish to pursue postdoctoral research on a topic of your expertise or in a significantly different field (the Human Frontier Science Program offers good options if this is your calling), writing a fellowship would be your go-to option.

A fellowship award in your CV also showcases your ability to lead funded research. Most fellowships also pay a little more than the standard postdoctoral salary and some interesting perks.

Now that you have decided on writing a fellowship, what should you look for in your host lab?

First, make sure you can justify how your work aligns with that of the host in terms of research interests and skill sets. Second, the host should be willing to support your application and research work with infrastructure available at the institute. After having interacted with many fellowship holders, I found that contrary to the popular belief, the name and fame of a host institute doesn’t necessarily aid or hinder the success of your application.

How long is a fellowship application process? Usually it takes a year’s time from start to finish. After finalising the host, it is wise to spend a good 3-4 months preparing for your research proposal. The application review process can take anywhere between 4 t0 9 months to complete. The time frame may also shift if there is only one application deadline a year, such as the Marie-Skłodowska Curie individual fellowship. Other fellowships, such as the one awarded by the Alexander von Humboldt foundation, accept applications throughout the year but evaluate them during specific periods usually mentioned on their website. It is best to submit your application at least a couple of months in advance of the next evaluation period.

How to nail a research proposal

This is the most important aspect. To begin with, make sure to carefully go through the application guidelines and always stick to them. I cannot emphasise enough how important and usually overlooked this point is. I have personally seen applicants not succeeding merely due to carelessness in following guidelines. Put in sincere effort and time to prepare the proposal.

Some quick points to keep in mind when drafting your proposal:

  • State the rationale, aims, objectives and timelines very clearly.
  • Make your proposal easy to read by organisingit under headings and sub-headings and using bolds and italics to emphasise points.
  • If the guidelines permit, insert a figure or two to illustrate your aim(s).
  • Be diligent when preparing and organising additional documents such as your CV, list of publications etc.

What makes an application successful? The originality, usefulness and innovative potential of a research proposal are key criteria of assessment of an application, in addition to the applicant’s academic record.

Caroline Kisker, Dean at the Graduate School of Life Sciences, University of Würzburg in Germany, who has served on the selection panel of many prestigious fellowships, says many factors play an important role in the success of an application. Was the student productive in his/her PhD thesis? Is the proposed research topic realistic for the period of the fellowship and sufficiently well described? Has the applicant made the effort to delve deeply into the topic and conveyed that he/she understands the topic well? Does the applicant consider possible pitfalls within the research proposal and provide suggestions on how do deal with them? She also strongly advises to avoid jargon and to write the proposal in a way that even a non-specialist can understand and evaluate it.

Writing a fellowship can be very rewarding in terms of the experience of the writing process itself. However, always be mindful that fellowships are usually very competitive. So even though you may have a decent track record and a good proposal, you may not get lucky always. It is always good to discuss this possibility with your host or look to for alternatives while your application is under consideration.

[Nazia Nasir can be reached at nazia.nasir85@gmail.com. She tweets from @NaziaPCL]

Suggested reading:

Beginnings – How to write your first grant proposal

A winning proposal