The 3D OrbiSIMS {credit}Courtesy of the National Physical Laboratory{/credit}
The current focus on single-cell biology reflects the growing awareness among life scientists that all cells are not alike.
In the genomics world, methods such as scRNA-seq and Drop-seq allow researchers to probe cellular heterogeneity at the genetic level using next-gen DNA sequencing. Mass spectrometry imaging (MSI) does likewise for protein and metabolite studies.