Five rules for starting up in synthetic biology

Building a synthetic biology startup is tough – but stay the course and it’ll be the most rewarding struggle of your life, says James Field.

Since the advent of life 3.6 billion years ago, the survival of all species has depended on rapid innovation at the genetic level. As a consequence, our planet has grown rich with evolved technologies.

Traditionally, the dream of harnessing these evolved technologies has been confined to thought experiments and science fiction. Now, the emerging field of synthetic biology is giving engineers the tools required to tap into evolution’s code-base.

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Study system envy

Graduate students must often weigh the pros and cons of straying from an advisor’s research program

Guest contributor Carolyn Beans

Early in graduate school, I had total study system envy. In many biological fields, including my own field of evolutionary ecology, a study system is a specific species that a scientist uses to run tests. Some of these species like mice, zebrafish, and the plant Arabidopsis are model organisms, and have been well-studied for decades or more. Whether scientists choose a model organism or a relatively unknown species as a study system can have drastic consequences for their research.

Zebrafish

Zebrafish{credit}Uri Manor, NICHD{/credit}

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Science communication: Life’s a pitch

Or: How to come out as a scientist to the public, your friends and family, when the latter paid for your degree and the former are paying for your current research, and all are slightly against the idea anyway because they were really hoping to get discounted wormers. Niche but translatable, like many PhDs!

Guest contributor Sophie Regnault

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Sophie and a 3D model of a tuatara skeleton made from CT scans, that was one of the Wellcome Images 2015 winners.{credit}Alexander Stoll{/credit}

Having started my PhD in evolutionary biomechanics a couple of years ago after a brief stint as a vet, one of the biggest challenges I’ve found is people’s attitude to science – the teenage, kiss-your-teeth, you’re-not-my-real-dad attitude.

Inside the Ivory Tower (our lab is at ground level, so perhaps Ivory Bungalow) other post-grads accept that my work is (probably) worthwhile, or they are suffering enough imposter syndrome themselves not to care. On the outside, people sometimes think that what I do isn’t worth it at all. Questions like “How is that important?”, “Why aren’t you doing something that benefits society?”, “When are you going to stop being a perpetual student and start contributing?” are responses to my job description.

Encountering this public attitude (at pubs, weddings, children’s birthday parties) is often the first experience we get of communicating science, and it’s an ideal practice ground. Being able to communicate science well is a vital skill because good communication perpetuates the value of science in society, defends funding, awakens new generations, and ultimately keeps knowledge alive (plus makes people think my job is worthwhile!). Continue reading