Human Pipettes: Scientific training and education in biomedical research

David Rubenson and Paul Salvaterra share their thoughts on a damaged and damaging research system

A recent cancer research symposium displayed a familiar asymmetry. 90% of the attendees were PhD students or postdocs sitting obsequiously in the rear and asking 10% of the questions. 10% of the attendees were front-sitting faculty providing 90% of the inquiries.

A simple case of youthful hesitancy and opaque presentations requiring years of experience to comprehend? But did individual Principal Investigators (PIs) meet with conference planners before advising their students to attend? Did conference planners consider the likely audience and ask speakers to modify their talks? And did faculty members attend the related trainee poster session?

 

Are junior scientists little more than human pipettes?

Are junior scientists little more than human pipettes?{credit}Paper Boat Creative/Getty{/credit}

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The three-year PhD program: good for students? Or too good to be true?

Calls to modernize the PhD to meet the demands of the job market are being answered by the introduction of a more streamlined three-year PhD program. But such changes are not necessarily in the best interests of students, say Alice Risely and Adam Cardilini

PhD students are the backbone of the research industry, often responsible for compiling precious datasets for their lab and learning the cutting-edge techniques required for analysis. But completing a PhD is hard, and getting harder as scientific standards creep steadily upwards. It takes over a year longer for current students to publish their first scientific paper than those 30 years ago because of the increasing data requirements of top journals. Across Europe and Australia, this is one reason why students are taking an average of four to six years (or longer) to complete their PhDs, despite candidature contracts usually being a maximum of four years, and government scholarships lasting at most three and a half years.

Delays in completion reflect badly on universities, and can threaten future funding. They can also threaten the job prospects of graduates, who are increasingly expected to have excellent time and project management skills for careers outside academia. In an attempt to combat lagging completion times and increase employability of graduates, universities are redesigning the PhD by rolling out three-year PhD programs. These shorter programs are intended to provide increased structural support to students, whilst also promoting broader and more applied skills required by non-academic employers. The catch is that these PhDs must be completed within three years, unless the student faces project delays that were unequivocally beyond their control. But is the three-year PhD program really in the best interests of all, or even most, students?

It will be harder to get PhD extensions under the new model.

It will be harder to get PhD extensions under the new model.

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Meditation on a Caltrain: Understanding where to travel to next

Exploring options and thinking laterally about where you can use your scientific skills might be the key to successfully transitioning into industry, learns George Busby.

This piece was one of two winners of the Science Innovation Union writing competition, Oxford.

“This is downtown San Francisco, our train’s final stop. Can all passengers please detrain? All detrain please. All detrain.” Perhaps it was the heady fug of jetlag that made this broadcast particularly amusing to my UK-English language sensibilities, but I “detrained” all the same and stepped into the crisp morning air of the Californian rush hour.

I was on the west coast to visit two genetics start-ups as part of a whirlwind three-day tour of the US. With a long postdoc and several first author papers tucked into my belt, I wanted to see if these credentials would pass muster in the tech haven of Silicon Valley. I’ve always found the loneliness of solo work-travel to be highly amenable to strategic thought, and this American adventure was an opportunity to reflect on why I was there and what I wanted.GettyImages-530306679-smaller

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The start and the middle: beginning your PhD

The initial stages of a PhD can be daunting. Fortunately, there are a few ways you can make the transition into productive doctoral study as smooth as possible.

Whether you’re starting a PhD fresh out of undergrad or after many years of employment, the decision to begin a doctorate is a significant career move. When I started, 18 months ago, I figured I had a pretty good idea of what I was getting into: I’d previously worked in industry, completed a Master’s degree, and worked as a research assistant in another lab.

But I soon realized that my PhD was different — in a number of ways — from what I’d done before. Here are some things I’ve learnt so far, and some ways I‘ve made efficient use of my brief time as a PhD student.

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Ghost research: taking stock of work that disappears

Why every researcher should keep an old bulletin board.

Guest contributor Eli Lazarus

I recently found a short article my father wrote for National Fisherman, in 1988, which reported on a new kind of lobster trap with a “catch escape panel” aimed at reducing bycatch. My dad had a steady freelance gig at the time with National Fisherman, and the article was one of several he wrote while researching “ghost traps” – lobster traps, specifically, but really any lost fishing gear (nets, lines) that disappears underwater for reasons random, accidental, or deliberate.

With lobster traps, it’s easy to imagine what happens. To retrieve traps and the lobsters in them, a fisher works her way along from floating buoy to buoy. Each is connected to a heavy “sink line” that is in turn fixed to a trap, which sits on the seabed, catching lobsters. If something – a propeller from a passing boat, for example – parts the sink line, then the buoy drifts off with the current and the trap is lost.

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{credit}Getty images/Jeff Rotman Photography{/credit}

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Postdocs and early-career researchers: be more than a name on a website

After a few months working as an associate editor at Nature Photonics, chief editor Oliver Graydon asked Gaia Donati if the role was what she had imagined it to be. She answered that in most aspects it had, with one significant exception: she hadn’t realised that finding referees to assess submitted manuscripts would be such a daunting task. Here, Gaia urges peer reviewers to make things easier by setting up a personal web page outlining their research experience and interests.

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Don’t stay in the shade, says Gaia Donati {credit}Patrick Michelberger {/credit}

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Away from home: Why the postdoc phase is crucial

We’re bringing you the best stories in lab mobility from Nature India

The ‘Away from home‘ blogging series features Indian postdocs working in foreign labs recounting their experience of working there, the triumphs and challenges, the cultural differences and what they miss about India. They also offer useful tips for their Indian postdocs headed abroad. You can join in the online conversation using the #postdochat hashtag.

In this post, microbiologist Devendra Dusane, a doctorate from the University of Pune and a postdoc at McGill University, Canada talks about the importance of the postdoc phase, which he says, is crucial for shaping one’s goals — both in life and in research. It is “overwhelming when my wife and daughter appreciate my published research papers and celebrate with me”, he says.

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Devendra Dusane with his family

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Omnity opens multilingual semantic searches up to academia

When preparing a grant or publication, where can you turn for new ideas? You can bounce ideas off colleagues, search PubMed and Web of Science for related literature, and maybe take a trip down Google lane. But it’s difficult to get outside one’s particular area of expertise — to mine the opportunities at cross-disciplinary boundaries  unless you know what you’re looking for. The developers of a new document search engine hope to make such cognitive leaps easier, finds Jeff Perkel.

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Why should we work so hard to make our work reproducible?

Most scientific work isn’t reproducible. Andy Tay explains why that’s a problem.

The call for reproducibility has never been stronger in the history of science. Since two major pharmaceutical companies, Amgen and Bayer, reported in 2011/12 that their scientists were unable to replicate 80-90% of the findings in landmark papers, scientific news outlets have caught up on the issue. Their reports have catalyzed conversations among stakeholders (policy makers, funding agencies and scientists) to improve reproducibility in science.

Copyright: LEGO

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There are a lot of reasons why reproducibility is so important, and why Amgen and Bayer’s results caused such controversy. I’ll start at the individual level. Continue reading

Why don’t scientists always share their data?

Reproducibility is the cornerstone of science, and it can be compromised by insufficient data in peer-reviewed publications. Should scientists reveal everything?

Publishing Better Science through Better Data writing competition winner Emma Vander Ende.

One of the foundations of science is its reproducibility. Without it, results are not verifiable and are therefore not believable. But even if a published result is true, there is a chance it might not be reproducible, which introduces a plethora of problems for science.

Irreproducible experiments severely limit the ability of the scientific community to build on results and advance the field. This can happen when scientists don’t share enough data, or details of their experiments in papers, and it happens quite frequently.

So why might a scientist not share their data?

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{credit}Comstock/Thinkstock{/credit}

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